The effect of pregnancy on meibomian gland,tear film,cornea and anterior segment parameters |
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| Institution: | 1. Department of Gynecology and Obstetrics, Konya City Hospital, Konya, Turkey;2. Department of Ophthalmology, Mardin Training and Research Hospital, Mardin, Turkey;1. Graduate School of Engineering, Faculty of Biomedical Engineering, Toin University of Yokohama, 1614, Kurogane-cho, Aoba-ku, Yokohama 225-8503, Japan;2. Department of Clinical Laboratory Medicine, Tokyo Women''s Medical University Hospital, 8-1, Kawada-cho, Shinjyuku-ku, Tokyo 162-8666, Japan;3. Department of Urology, Tokyo Women''s Medical University, 8-1, Kawada-cho, Shinjyuku-ku, Tokyo 162-8666, Japan;4. Department of Laboratory Medicine, National Taiwan University Hospital, No. 7, Zhongshan S. Rd., Taipei 10002, Taiwan;5. Department of Surgical Pathology, Tokyo Women''s Medical University, 8-1, Kawada-cho, Shinjyuku-ku, Tokyo 162-8666, Japan;1. Ümraniye Training and Research Hospital Ophthalmology Department, Turkey;2. Kartal Lütfi Kırdar Training and Research Hospital Ophthalmology Department, Turkey;3. Moorfields Eye Hospital, United Kingdom;4. T.C. Istanbul Demiroğlu Bilim University Medical Faculty Ophthalmology Department, Turkey;5. T.C. Istanbul Demiroğlu Bilim University Medical Faculty Neurosurgery Department, Turkey;1. Department of Ophthalmology, Yildirim Beyazit University Medical School, Universiteler Avenue 1604 street no:9, Cankaya, Ankara, Turkey;2. University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey;3. Adiyaman Education and Research Hospital, Department of Ophthalmology, Adiyaman, Turkey;4. Adiyaman University Medical School, Department of Ophthalmology, Adiyaman, Turkey;1. Faculty of Health Sciences, Izmir Katip Çelebi University, Izmir Kâtip Çelebi Üniversitesi Balatçık Kampüsü, Çiğli, İzmir 35620, Turkey;2. Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Ege University, Turkey;3. Faculty of Engineering, Department of Biomedical Engineering, İzmir Katip Çelebi University, Turkey;4. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ege University, Turkey;6. Faculty of Medicine, Department of Microbiology, İzmir Katip Çelebi University, Turkey;1. Dermatology Department, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, Guangdong, PR China;2. Dermatology Department, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, PR China |
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| Abstract: | AimIn this prospective study, we aimed to examine the effect of physiological and pathological changes that occur during pregnancy in regard to Meibomian Gland (MG) structure, tear film, cornea and anterior segment parameters.MethodsThe following groups were compared: 49 eyes of 49 pregnant women at 16-20 weeks of pregnancy (P16 Group), 46 eyes of 46 pregnant women at 32-36 weeks of pregnancy (P32 Group) and 51 eyes of 51 participants who were not pregnant (P0 Group). The groups were compared in terms of the first break-up time (NIF-BUT) and average break-up time (NIAvg-BUT) values. Non-contact meibography and MG loss rates were also compared.ResultsThe groups were found to be compatible in terms of age (P=0.052). The mean NIF-BUT values in the P16, P32 and P0 groups were 4.7 ±2.7, 6 ±3 and 6.7 ±3.1 seconds, respectively (P=0.055). The mean MG loss rates for the upper lid in the P16, P32 and P0 groups were 35.3%±12.6, 33.4%±11.4 and 15.5%±5.4, respectively. The loss rates for the lower lid in the P16, P32 and P0 groups were found to be 40.5%±18.6, 40.5%± 14.4 and 20.1%±8.1, respectively (P=0.000, p=0.000). The mean anterior chamber value (ACV) was found in the P16, P32 and P0 groups with 160.8 ±31.8, 150.9 ±26.5 and 165.9 ±26.5 µm3, respectively (P=0.035).ConclusionMG loss was found to be higher in pregnant groups compared to the non-pregnant groups. We found minimal instability in the tear film of the pregnant groups. We believe that pregnant women should be followed closely in terms of ocular surface diseases. |
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