Evaluating the efficacy of photodynamic therapy with indocyanine green in the treatment of keloid |
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| Affiliation: | 1. Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department and Research Center of Medical Physics, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Drug and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Ophthalmology, Alanya Alaaddin Keykubat University Faculty of Medicine, Antalya, Turkey;2. Department of Ophthalmology, Health Sciences University Antalya Training and Research Hospital, Antalya, Turkey;3. Department of Rheumatology, Health Sciences University Antalya Training and Research Hospital, Antalya, Turkey;4. Department of Internal Medicine, Health Sciences University Antalya Training and Research Hospital, Antalya, Turkey;1. Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul 34752, Turkey;2. Department of Neurology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul 34752, Turkey;1. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China;2. Department of Endocrinology, Suzhou Hospital of Anhui Medical University (Suzhou Municipal Hospital of Anhui Province), Suzhou, China;3. Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia;4. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK;5. Stridon Clinical Research, Richmond upon Thames, UK;6. Department of General Practice, Zhongda Hospital; Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China;7. Research and Education Centre of General Practice, Zhongda Hospital, Southeast University, Nanjing, China;1. University of Health Sciences, Turkey Beyoglu Eye Training and Research Hospital, Turkey;2. Edirne Sultan 1st Murat State Hospital, Edirne, Turkey;3. Prof Dr Cemil Tascioglu City Hospital, İstanbul, Turkey;1. Fatih Sultan Mehmet Training and Research Hospital, Departmant of Ophtalmolgy, Istanbul, Turkey;2. Emory Eye Center, Atlanta, United States;1. Eye Unit, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy |
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| Abstract: | BackgroundThis study aimed to evaluate the efficacy of photodynamic therapy (PDT) with topical indocyanine green (ICG) in the treatment of keloid lesions.MethodsIn this pilot study, fifteen keloids (6 lesions on the sternal area, 3 on the shoulders, 2 on the abdomen, 2 on the legs, and 2 on the forearms) were selected. To enhance drug penetration, pretreatment with CO2 laser was performed. Then Lesions were covered with 0.2% transfersomal ICG gel with 1 mm thickness and occluded with light-proof plastic nylon for 2 h. Afterward, it was wiped off and underwent photodynamic therapy with source LumaCare with 730 nm probe and fluence of 23 J/cm2 every week for 6 sessions. Patients were also assessed 6 and 12 weeks after the treatment for any recurrences. The Patient and Observer Scar Assessment Scale (POSAS) was used to evaluate the scars.ResultsThe mean POSAS score significantly reduced by 23.69% from 46.86 at baseline to 35.76 at the 6th treatment session (P< 0.001). The mean scores of patient and observer overall opinion significantly decreased by 16.35% (P< 0.001) and 12.31% (P = 0.001) respectively. No side effects were observed during treatment and after 3 months of follow-ups. After discontinuation of therapy, the mean score of POSAS significantly increased by 13.77% to 40.80. (P = 0.001)ConclusionAccording to our study, ICG-PDT is an effective and safe treatment for keloid. However, due to the recurrence following discontinuation of treatment, further studies are needed. |
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