Quality of life following photodynamic therapy for head and neck pathologies: An exploratory study |
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| Affiliation: | 1. North End Medical Centre, London, United Kingdom;2. UCL Medical School, London, United Kingdom;3. Imperial College School of Medicine, London, United Kingdom;4. UCL Eastman Dental Institute, London, United Kingdom;5. University of Sharjah, Sharjah, UAE;6. UCLH Head and Neck Unit, London, United Kingdom;1. Department of Clinical Laboratory Science, Daejeon Health Institute of Technology, Daejeon, Republic of Korea;2. Department of Radiological science, Jeonju university, Jeonju, Republic of Korea;3. PDT Research Center, Dr.InB Co., Daejeon 34047, Republic of Korea;1. University of Health Sciences, Turkey Beyoglu Eye Training and Research Hospital, Turkey;2. Edirne Sultan 1st Murat State Hospital, Edirne, Turkey;3. Prof Dr Cemil Tascioglu City Hospital, İstanbul, Turkey;1. Isfahan Eye Research Center, Department of ophthalmology, Isfahan University of medical sciences, Isfahan, Iran;2. Shahrekord university of medical sciences, Iran;1. Department of Ophthalmology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China;1. Department of Ophthalmology, Fatih Sultan Mehmet Training and Research Hospital, Health Science University, Hastane Sokak no:1/8. İçerenköy, Ataşehir, İstanbul 34752, Türkiye;2. Department of Ophthalmology, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Health Science University, Cevizli, D-100 Güney Yanyol, Cevizli Mevkii No:47, Kartal, İstanbul 34865, Türkiye;3. Department of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital, Health Science University, Hastane Sokak no: 1/8. İçerenköy, Ataşehir, İstanbul 34752, Türkiye |
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| Abstract: | IntroductionHealthcare related quality of life (QoL) is defined as the impact one's level of health and wellbeing has on a number of domains, including physical, mental, spiritual and social functions. Photodynamic therapy (PDT), a cancer treatment modality, is increasingly used to treat or palliate head and neck pathologies. Due to the complex nature of this area of the body, both the pathology and the treatment of it can severely affect the quality of life. Thus far, no questionnaire has been developed which focuses on quality-of-life post-PDT of head and neck pathologies.Patients and methodsWe have developed the University College London Quality of Life Questionnaire for Patients undergoing PDT in the Head and Neck, using meta-tetra(hydroxyphenyl)chlorin (mTHPC) as the photosensitiser. This was modified from the University of Washington quality of life (UW-QOL) questionnaire. Thirty-eight patients who received mTHPC-PDT for various head and neck pathologies completed the questionnaire, with a mean follow-up of 56 days.ResultsAll patients reported improved QoL following mTHPC-PDT. The main problem that was reported was post-PDT pain, which is a common side effect. Visual symptoms, breathing, speaking and swallowing problems improved significantly in the 4th week following treatment and significant improvement in activities of daily living, social life, mood and anxiety were reported in the subsequent weeks.ConclusionsmTHPC-PDT confers improvement in QoL score in selected head and neck cancer patients with figures comparable to other treatment modalities. This exploratory study demonstrated patterns of QoL outcome. Further work needs to be done for survey validation and inclusion of a larger cohort which will allow optimal sub-group analysis and help guide further interventions. |
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| Keywords: | Photodynamic therapy Quality of Life |
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