Antimicrobial photodynamic therapy in endodontic reintervention: A systematic review and meta-analysis |
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| Affiliation: | 1. Department of Preventive and Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Rua José Bonifácio, 1193, Araçatuba, SP 16015-050, Brazil;2. Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araraquara, SP, Brazil;3. Department of Dental Materials and Prosthodontics, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil;1. Department of Preventive and Restorative Dentistry, São Paulo State University (UNESP) School of Dentistry, Araçatuba, SP, Brazil;2. Department of Restorative Dentistry, São Paulo State University (UNESP) School of Dentistry, Araraquara, SP, Brazil;1. Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, SP, Brazil;2. Department of Health Sciences and Pediatric Dentistry, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, SP, Brazil;3. Special Laboratory of Lasers in Dentistry (LELO), Department of Restorative Dentistry, School of Dentistry, University of São Paulo, SP, Brazil;4. Department of Endodontology, Academic Centre for Dentistry of Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands;1. Department of Dental Materials and Prosthodontics, Araçatuba School of Dentistry, São Paulo State University (UNESP), Araçatuba, SP, Brazil;2. Department of Preventive and Restorative Dentistry, Discipline of Endodontics, Araçatuba School of Dentistry, São Paulo State University (UNESP), Rua José Bonifácio, 1193, Araçatuba, SP 16015-050, Brazil;3. Department of Surgery and Integrated Clinic, Araçatuba School of Dentistry, São Paulo State University (UNESP), Araçatuba, SP, Brazil;4. Department of Basic Sciences, Araçatuba School of Dentistry, São Paulo State University (UNESP), Araçatuba, SP, Brazil |
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| Abstract: | BackgroundTo evaluate the effectiveness of the use of antimicrobial photodynamic therapy (aPDT) in root canals disinfection in cases of endodontic retreatments.MethodsThis Systematic Review was registered in PROSPERO (CRD42021260013) and followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Searches were performed in the electronic databases PubMeb, Scopus, Web of Science, Embase, Web of Science, Clinical Trials and Cochrane Library. Methodological quality and risk of bias were assessed by the Cochrane Risk of Bias tool for randomized clinical trials (RCT) and by the Newcastle-Ottawa (NOS) qualifier for non-RCT (prospective) studies. Meta-analysis was performed using R software, version 3.6.3 with the “META” package assistant by the RStudio platform. The odds ratio (OR) measure of effect was calculated and the random effect model was applied with a 95% confidence interval, and heterogeneity tested by the I2 index. The certainty of evidence was rated using GRADE.ResultsRegarding the 1513 studies screened, 10 met the eligibility criteria and were included, and 8 used in the quantitative synthesis. Meta-analysis showed that all of studies data presented a significant difference before and after of antimicrobial photodynamic therapy in the microbial load reduction in secondary endondontic infections (OR 0.15 [0.07; 0.32], p < 0.0001). Overall, the studies had a low risk of bias and, the analysis of evidence by GRADE assessment was rated as moderate.ConclusionIt is suggested that aPDT is a beneficial and promising tool, showing efficacy in reducing the microbial load in cases of endodontic retreatment. |
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| Keywords: | Photodynamic therapy |
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