Pharmacokinetics,bioavailability and withdrawal period of antibiotic oxytetracycline in catfish Pangasianodon hypophthalmus |
| |
| Affiliation: | 1. Department of Aquatic Animal Health, Faculty of Fishery Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700094, India;2. Department of Veterinary Pharmacology, Faculty of Veterinary and Animal Sciences, West Bengal University of Animal and Fishery Sciences, Chakgaria, Kolkata 700037, India;3. Fish Processing Division, ICAR-Central Institute of Fisheries Technology, Willington Island, Cochin 682029, India;4. Aquatic Animal Health and Environment Division, ICAR-Central Institute of Brackishwater Aquaculture, Raja Annamalai Puram, Chennai 600028, India;1. Fish Health Management Division, ICAR-Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar 751012, Odisha, India;2. Biotechnology Laboratory, ICAR-Central Inland Fisheries Research Institute, Barrackpore, Kolkata 700120, West Bengal, India;3. Department of Bioinformatics, Orissa University of Agriculture and Technology, Bhubaneswar 751003, Odisha, India;4. KBDAV College, Nirakarpur, Odisha, India;1. Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand;2. Animal Virome and Diagnostic Development Research Group, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand;3. Department of Veterinary Microbiology and Immunology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand;4. Interdisciplinary Graduate Program in Genetic Engineering and Bioinformatics, The Graduate School, Kasetsart University, Bangkok 10900, Thailand;5. National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathumthani 12120, Thailand;6. Clemson Veterinary Diagnostic Center, Clemson University, Columbia, SC 29229, United States of America |
| |
| Abstract: | The antibiotic oxytetracycline (OTC) has been widely used for therapeutic and preventive management of bacterial diseases in finfish and shellfish. In the present study the bioavailability, pharmacokinetics, and withdrawal period of the OTC have been determined following in-feed administration in intensively cultured catfish Pangasianodon hypophthalmus. Furthermore, the pharmacokinetic parameters of oral route were also compared with parenteral route. Drug concentrations were measured in various tissues at different time intervals by LC-MS/MS. The study revealed the drug kinetics best followed the enterohepatic circulation model with very poor bioavailability and low blood concentration after oral administration. In the withdrawal study, after 10-days of in-feed administration at the therapeutic dose the drug reached very high concentrations in the liver and kidneys but did not attain minimum inhibitory concentrations (MICs) in blood or flesh. OTC concentration also did not exceed the recommended MRL value in flesh; however, considering high amounts of the chemical in the liver and kidneys a withdrawal period of 4 days (at 28 ± 1.5 oC) is recommended for consumer safety. Poor bioavailability and non-attainment of minimum therapeutic concentration in blood and flesh do not warrant in-feed administration of OTC for control of bacterial diseases in P. hypophthalmus.Availability of data and materialsAll data generated and analyzed during this study are included in this article. Raw data may be shared upon reasonable request. |
| |
| Keywords: | Tetracycline Pangasius Pharmacokinetics Oral Parenteral |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
