ATP-sensitive potassium channels: A double-edged sword in neurodegenerative diseases |
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| Affiliation: | 1. National Clinical Research Center for Obstetrical and Gynecological Diseases; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China;2. National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei 430030, China;3. Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei 430030, China;4. Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China;1. Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China;2. University Research Facility in Behavioral and Systems Neuroscience, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China;1. Metabolism, Nutrition and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Londrina, Paraná, Brazil;2. Applied Physiology, Nutrition and Exercise Research Group, Exercise Biology Research Lab (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil;3. Applied Physiology & Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil;4. University Center of Planalto de Araxá (UNIARAXA), Araxá, Minas Gerais, Brazil;5. Department of Physical Education, Minas Gerais State University (UEMG), Passos, Minas Gerais, Brazil;6. Navarrabiomed, Hospital Universitario de Navarra (HUN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain;7. CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain;8. School of Physical Education, Physiotherapy and Dance, Exercise Research Laboratory, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil;1. Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia;2. Czech National Centre for Evidence-Based Healthcare and Knowledge Translation, (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic;3. Independent researcher, Bangalore, India;4. Department of Nursing and Midwifery, Faculty of Medicine, Masaryk University, Brno, Czech Republic;5. Emeritus Director Respiratory Medicine, and VMO Acute Medicine, The Alfred Hospital, Melbourne;6. School of Public Health and Prevention Medicine, Monash University, Melbourne, Victoria, Australia;7. Department of Neurology, Royal Hobart Hospital, Hobart, Australia;1. Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Italy;2. Gérontopôle de Toulouse, Institut du Vieillissement, CHU de Toulouse, France;3. UMR INSERM 1295, Université Toulouse III, France;4. EA4468 Université de Paris, France;5. Service de gériatrie, Hôpital Broca, AP-HP, Hôpitaux Universitaires Paris Centre, France |
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| Abstract: | ATP-sensitive potassium channels (KATP channels), a group of vital channels that link the electrical activity of the cell membrane with cell metabolism, were discovered on the ventricular myocytes of guinea pigs by Noma using the patch-clamp technique in 1983. Subsequently, KATP channels have been found to be expressed in pancreatic β cells, cardiomyocytes, skeletal muscle cells, and nerve cells in the substantia nigra (SN), hippocampus, cortex, and basal ganglia. KATP channel openers (KCOs) diazoxide, nicorandil, minoxidil, and the KATP channel inhibitor glibenclamide have been shown to have anti-hypertensive, anti-myocardial ischemia, and insulin-releasing regulatory effects. Increasing evidence has suggested that KATP channels also play roles in Alzheimer's disease (AD), Parkinson's disease (PD), vascular dementia (VD), Huntington's disease (HD) and other neurodegenerative diseases. KCOs and KATP channel inhibitors protect neurons from injury by regulating neuronal excitability and neurotransmitter release, inhibiting abnormal protein aggregation and Ca2+ overload, reducing reactive oxygen species (ROS) production and microglia activation. However, KATP channels have dual effects in some cases. In this review, we focus on the roles of KATP channels and their related openers and inhibitors in neurodegenerative diseases. This will enable us to precisely take advantage of the KATP channels and provide new ideas for the treatment of neurodegenerative diseases. |
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| Keywords: | Neurodegenerative diseases |
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