Translational and pharmacological principles of hyperthermic intraperitoneal chemotherapy for ovarian cancer |
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| Affiliation: | 1. Dept. of Gynecologic Oncology, Center for Gynecologic Oncology, Amsterdam, Netherlands Cancer Institute, Amsterdam, the Netherlands;2. Dept. of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands;3. Dept. of Pharmacology, Netherlands Cancer Institute, Amsterdam, the Netherlands;4. Dept. of Clinical Pharmacy, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands;5. Dept. of Pharmacology, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands;6. Dept. of Obstetrics and Gynecology, Sint Antonius Hospital, Nieuwegein, the Netherlands;1. Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India;2. Department of Radiation Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India;3. Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India;1. Department of Haematology-Oncology, National University Cancer Institute, 1E Kent Ridge Road, National University Health System Tower Block Level 7, 119228, Singapore;2. Cancer Science Institute, National University of Singapore, 14 Medical Drive, 117599, Singapore;3. Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, 117597, Singapore;1. Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands;2. GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands;3. Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;4. Divisions of Diagnostic Oncology and Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;5. Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands |
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| Abstract: | The long-term survival of advanced-stage ovarian cancer patients remains poor, despite extensive cytoreductive surgery, chemotherapy, and the recent addition of poly (ADP-ribose) polymerase inhibitors (PARPi). Hyperthermic intraperitoneal chemotherapy (HIPEC) has shown survival benefit by specifically targeting peritoneal metastases, the primary site of disease recurrence. Different aspects of how HIPEC exerts its effect remain poorly understood. Improved understanding of the effects of hyperthermia on ovarian cancer cells, the synergy of hyperthermia with intraperitoneal chemotherapy, and the pharmacological and pharmacokinetic properties of intraperitoneally administered cisplatin may help identify ways to optimize the efficacy of HIPEC. This review provides an overview of these translational and pharmacological principles of HIPEC and aims to expose knowledge gaps that may direct further research to optimize the HIPEC procedure and ultimately improve survival for women with advanced ovarian cancer. |
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| Keywords: | Ovarian cancer Hyperthermic intraperitoneal chemotherapy Translational medical research Hyperthermia Pharmacology Pharmacokinetics |
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