Normative data assessment of age-related changes in macular and optic nerve head vessel density using optical coherence tomography angiography |
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| Institution: | 1. Kırşehir Ahi Evran Training and Research Hospital, Department of Opthalmology, Kırşehir, Turkey;2. Polatlı Duatepe State Hospital, Department of Opthalmology, Ankara, Turkey;3. Necmettin Erbakan University Meram Medical Faculty Hospital, Department of Opthalmology, Konya, Turkey;1. Hamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California, San Diego, La Jolla, California;2. Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea;1. Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania;2. Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania;1. Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA;2. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA;3. Department of Ophthalmology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, South Korea;4. Ophthalmology Department, San Raffaele University Hospital, Milan, Italy;1. Department of Glaucoma, Narayana Nethralaya Eye Hospital, Rajajinagar, Bangalore, India;2. Department of Glaucoma, Narayana Nethralaya Eye Hospital, Hulimavu, Bangalore, India;3. University Eye Clinic Maastricht, University Medical Center, Maastricht, The Netherlands;1. Department of Bioengineering, University of Washington, Seattle, Washington, USA;2. Department of Ophthalmology, University of Washington, Seattle, Washington, USA |
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| Abstract: | ObjectiveTo investigate macular and optic nerve head vessel density in healthy individuals using optical coherence tomography angiography (OCTA), and determine their relationship with age.MethodThis retrospective study included 153 eyes of 153 individuals aged between 20 and 80 years, who had no systemic diseases, optic disk, or retinal pathologies. The retinal (6 × 6 mm) and optic disk (4.5 × 4.5 mm) OCTA images were evaluated for superficial capillary plexus (SCP), deep capillary plexus (DCP) and radial peripapillary capillary plexus (RPCP) vessel density, foveal avascular zone (FAZ) area, and choriocapillaris flow area and compared among 5 age groups.ResultsThe SCP vessel density was significantly associated with age for the whole image (P = 0.001), parafovea (P = 0.038), and perifovea (P/ce:italic>= 0.001). The DCP vessel density significantly varied with age in the whole image (P = 0.004), parafovea (P = 0.001), and perifovea (P = 0.002). The SCP and DCP vessel densities were significantly lower in the older age groups, and more prominently so after 50 years of age. The FAZ area increased with age; however, this finding was not statistically significant (P = 0.660). The choriocapillaris flow area decreased with age (P = 0.002). The RPCP vessel density in the inside disk significantly decreased with age (P = 0.038).ConclusionAge should be taken into consideration when using OCTA in the diagnosis and follow-up of retinal and optic nerve diseases. It is believed that the results here in can be used as a reference baseline for future studies. |
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