Blood pressure variability: A potential marker of aging |
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| Affiliation: | 1. Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Italy;2. Gérontopôle de Toulouse, Institut du Vieillissement, CHU de Toulouse, France;3. UMR INSERM 1295, Université Toulouse III, France;4. EA4468 Université de Paris, France;5. Service de gériatrie, Hôpital Broca, AP-HP, Hôpitaux Universitaires Paris Centre, France;1. CNC, Center for Neuroscience and Cell Biology, University of Coimbra Polo 1, Coimbra, Portugal;2. FMUC- Faculty of Medicine, University of Coimbra Polo 3, Coimbra, Portugal;3. III, Institute of Interdisciplinary Research, University of Coimbra, Coimbra, Portugal;1. Academic Unit for Psychiatry of Old Age, University of Melbourne, Parkville, Australia;2. Department of Psychology, Umeå University, Umeå, Sweden;3. Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Camperdown, Australia;4. Central Clinical School, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Camperdown, Australia;5. Department of Social and Psychological Studies, Karlstad University, Karlstad, Sweden;6. Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany;7. Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany;1. Department of Applied Health Sciences, Hochschule für Gesundheit (University of Applied Sciences), Bochum, Germany;2. Department of Clinical Gerontology, Robert-Bosch-Hospital, Stuttgart, Germany;3. HSD Hochschule Döpfer (University of Applied Sciences), Department of Health, Cologne, Germany;4. Faculty of Sports Science, Ruhr-University Bochum, Bochum, Germany;5. Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany;6. Department of Therapy Science I, Brandenburg Technical University Cottbus - Senftenberg, Senftenberg, Germany;7. Digital Geriatric Medicine, Medical Clinic, Heidelberg University, Germany;1. Metabolism, Nutrition and Exercise Laboratory, Physical Education and Sport Center, Londrina State University, Londrina, Paraná, Brazil;2. Applied Physiology, Nutrition and Exercise Research Group, Exercise Biology Research Lab (BioEx), Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil;3. Applied Physiology & Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil;4. University Center of Planalto de Araxá (UNIARAXA), Araxá, Minas Gerais, Brazil;5. Department of Physical Education, Minas Gerais State University (UEMG), Passos, Minas Gerais, Brazil;6. Navarrabiomed, Hospital Universitario de Navarra (HUN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain;7. CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain;8. School of Physical Education, Physiotherapy and Dance, Exercise Research Laboratory, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil |
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| Abstract: | Aging is characterized by alterations in neuro-cardiovascular regulatory mechanisms, leading to impaired physiological variability patterns. Repeated evidence has shown that increased Blood Pressure Variability (BPV) is associated with organ damage and exerts independent predictive value on several health outcomes: cardiovascular events, neurocognitive impairment, metabolic disorders and typical geriatric syndromes such as sarcopenia and frailty. Accordingly, it may constitute the epiphenomenon of the alterations in homeostatic mechanisms, typical of late life.Aging and altered BPV share the same molecular mechanisms, in particular the clinical state of subclinical inflammation has been widely ascertained in advanced age and it is also related to BP dysregulation through altered endothelial function and increased production of ROS. Arterial stiffness and autonomic dysfunction have been associated to impairment in BPV and also represent key features in elderly patients. Furthermore, accumulating evidence in the field of Geroscience has reported that several molecular changes described in cardiovascular aging and altered BPV also relate with the majority of the 9 identified hallmarks of aging. Indeed, BPV may be linked to genomic instability, epigenetic modification and mitochondrial oxidative damage, which represent milestones of aging process.The aim of the present paper is to analyse the interplay between BPV and the pathophysiology of the ageing process, in order to stimulate discussion about the potential role of BPV as a new marker of aging. |
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| Keywords: | Blood Pressure Variability Aging Marker Hallmarks Hypertension |
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