降钙素原用于脓毒症早期诊断的临床价值

目的研究降钙素原用于脓毒症早期诊断的临床价值。方法选择新进入ICU患者60例，根据全身炎症反应综合征（SIRS）和脓毒症诊断标准分为非感染SIRS组（32例）和脓毒症组（28例）。分别记录和比较两组患者人院1d和4d降钙素原（PCT）、CRP、WBC、ESR、中性粒细胞比率（N）、血小板（PLT）及最高体温（T）。结果脓毒症组PCT（6．73±1．31）ng／mL，显著高于非感染性SIRS组的（0．25±0．05）ng／mL（t=3．10，P〈0．05）。PCT的ROC曲线下面积0．869，显著大于CRP（0．717）、WBC（0．798）、N（0．737）和ESR（0．394）（均P〈0．05）。结论血降钙素原是脓毒症早期诊断的一个良好指标，其敏感性和特异性高于其他的炎性指标。

Clinical value of procalcitonin on early diagnosis of sepsis

Objective To study the clinical value of procalcitonin on early diagnosis of sepsis. Methods 60 patients who entered ICU were enrolled in the present study were chosen. The change of procalcitonin, CRP, WBC, ESR, GRANR and the highest temperature was observed dynamically with 1 day and 4 days in hospitalization. The patients were ultimately divided into the two groups according to the diagnostic standard of sepsis ,the sepsis group （SIRS group） and infective systemic inflammatory response syndrome group.（ NONSIRS group）. Results After ana- lyzing the processed data,researchers found that PCT of the sepsis group（6.73 ± 1.31 ） ng/mL was higher evidently than that of the SIRS group （0.25 ± 0.05 ） ng/mL （ t = 3.10, P 〈 0.05 ）, the area under ROC curve of PCT （0.869） is evidently greater than CRP （0.798）, WBC （0.737） and ESR （0.394） （P 〈 0.05 ）, which had statistical significance. Conclusion Procalcitonin is a good index of early diagnosis on sepsis,therefor,its sensitivity and specificity is higher than the other inflammatory indicators. Finally, procalcitonin can be widely used in clinical trial.