度洛西汀与加巴喷丁治疗糖尿病周围神经炎的疗效比较

目的：比较度洛西汀与加巴喷丁治疗糖尿病周围神经炎的疗效与安全性。方法将135例糖尿病周围神经炎患者按随机数字表法分为观察组（71例）和对照组（64例），所有患者根据糖尿病治疗原则进行降血糖治疗。此外，观察组患者接受口服度洛西汀治疗，对照组患者接受口服加巴喷丁治疗。在治疗前以及治疗后第1、2、4周末采用视觉模拟评分法（VAS）、健康调查简易量表（SF-36）对患者进行疼痛评分并记录患者治疗过程中的不良反应。结果（1）与治疗前比较，两组治疗后第1、2、4周末的VAS评分、SF-36评分均显著下降（均P＜0．05），但两组相同时间点的VAS评分、SF-36评分差异均无统计学意义（均P＞0．05）。（2）观察组口干、嗜睡、乏力、眩晕等不良反应发生率显著低于对照组（18．31％比34．38％，4．23％比26．56％，0.00％比23．44％，0．00％比15．63％，χ2＝4．059、13．308、4．059、4．059，均P＜0．05），两组恶心、心悸、腹泻等不良反应发生率相比差异均无统计学意义（均P＞0．05）。结论度洛西汀与加巴喷丁治疗糖尿病周围神经炎的疗效相当，但是度洛西汀的安全性更好。

Comparison of the efficacy of duloxetine and gabapentin in the treatment of diabetic peripheral neuritis

Objective To compare the efficacy and safety of duloxetine and gabapentin in the treatment of diabetic peripheral neuritis .Methods 135 patients with diabetic peripheral neuritis were divided into the observation group（71 cases） and the control group （64 cases） according to random number table method ,and all patients received hypoglycemic therapy based on diabetes treatment principle .Furthermore,the observation group received oral duloxe-tine,while the control group was given oral gabapentin .The pain scores of all patients were evaluated using visual ana-log scale（VAS） and medical outcomes study （SF-36）,and the adverse reactions were recorded during treatment . Results （1） Compared with before treatment ,both VAS scores and SF-36 scores in observation group and control group declined significantly at the end of 1st,2nd,4th week after treatment（all P〈0.05）,while there were no statis-tically significant differences in VAS scores and SF-36 scores between the two groups at the same time point （ all P〉0.05）.（2）The incidence rates of dry mouth ,drowsiness,fatigue and dizziness in observation group were significantly lower than those in control group （18.31% vs.34.38%,4.23% vs.26.56%,0.00% vs.23.44%,0.00% vs. 15.63%,χ2 =4.059,13.308,4.059,4.059,all P〈0.05）,while there were no statistically significant differences in incidence rates of nausea ,diarrhea and flustered between the two groups （all P〈0.05）.Conclusion The duloxetine and gabapentin in the treatment of diabetic peripheral neuritis have similar efficacy , but the duloxetine has better security.