布林佐胺治疗钝挫伤性机械性眼外伤的临床疗效

目的：观察应用布林佐胺滴眼液治疗钝挫伤性机械性眼外伤的临床效果。方法选取钝挫伤性机械性眼外伤患者50例（57眼），采用随机数字分组法分为观察组和对照组各25例（观察组29眼；对照组28眼）。两组患者均采取相应的眼球钝挫伤治疗方法，观察组加用布林佐胺滴眼液滴眼。观察两组视力、眼压、视网膜电图变化情况。结果治疗后观察组视功能明显优于对照组（χ2＝4．49，P＜0．05）；观察组眼压（14．88±0．83）mmHg，明显低于对照组的（19．64±2．30）mmHg（P＜0．05）；两组治疗后a、b波振幅总和显著优于治疗前，且观察组显著高于对照组（观察组ta ＝0．44，tb＝0．24；对照组ta＝1．03，tb ＝0．32；组间比较：ta ＝3．35，tb ＝2．37，均P＜0．05）。结论应用布林佐胺滴眼液进行预防性治疗钝挫伤性机械性眼外伤，可明显提高患者视力，控制患者眼压，促进视网膜功能恢复，具有积极的临床效果。

Clinical efficacy of brinzolamideon mechanical contusion ocular trauma

Objective To observe clinical efficacy of brinzolamide on mechanical contusion ocular trauma . Methods 50 patients（57 eyes） of mechanical contusion ocular trauma were selected and divided into observation group and control group randomly and evenly （ 29 eyes in the observe group ,28 eyes in the control group ） .On the basis of mechanical contusion ocular trauma basic treatment for all the patients , the observing group was added brinzolamide ophthalmic suspension .Their vision , intraocular pressure and ERG were observed .Results The vision of patients in the observing group was obviously better than that in the control group （χ2 =4.49,P〈0.05）.Intraocular pressure in the observing group （14.88 ±0.83）mmHg was obviously lower than that in the control group （19.64 ± 2.30）mmHg（P〈0.05）.Sum of a-wave amplitude and sum of b-wave amplitude after treatment were better than those before treatment ,and those in the observing group were higher than theose in the control group （ observation group：ta =0.44,tb =0.24;the control group：[ ta =1.03,tb =0.32;between two grous：ta =3.35,tb =2.37,P〈0.05 ） ] .Conclusion Using Brinzolamide ophthalmic suspension to treat mechanical contusion ocular trauma preven -tively can obviously improve patients′vision, control their intraocular pressure and promote the recovery of retinal function.It has positive clinical effect .