血清内皮素、单核细胞趋化蛋白和基质金属蛋白酶-9水平与冠心病的关系研究

目的探讨血清内皮素（ET-1）、单核细胞趋化蛋白（MCP-1）和基质金属蛋白酶-9（MMP-9）水平与不同类型冠心病的关系。方法80例冠心病患者，按不同类型分为急性心肌梗死（AMI）组22例、不稳定型心绞痛（UAP）组33例、稳定型心绞痛（SAP）组25例，另选择30例健康体检者作为对照组。采用ELISA法检测血清ET-1、MCP-1和MMP-9的水平，比较各组间的差异。结果四组血清ET-1（F=17．36）、MCP-1（F=13．51）和MMP-9（F=15．43）水平差异均有统计学意义（均P〈0．05）。组间比较：AMI组、UAP组及SAP组较对照组高（t=5．12、5．35、5．15、4．22、4．65、4．54、3．12、3．65、3．54，均P〈0．05）；AMI组、UAP组较SAP组高（t=4．32、4．15、4．52、3．54、3．23、3．51，均P〈0．05）；AMI组较UAP组高（t=3．78、3．96、3．56，均P〈0．05）。结论血清ET-1、MCP-1和MMP-9可能是冠状动脉粥样硬化的标志，参与了冠心病的发病机制，与冠状动脉病变程度密切相关。

Relationship of the levels of serum ET-1, MCP-1 and MMP-9 in coronary heart disease

Objective To study the relationship of the levels of serum ET-1 ,MCP-1 and MMP-9 in patients with different type coronary heart disease （CHD）. Methods 80 CHD patients were divided into 3 groups,including 22 cases of acute myocardial infarction （AMI） ,33 cases of unstable angina （UAP） ,25 cases of stable angina （SAP） and control group consisted of 30 healthy people. The levels of ET-1, MCP-1 and MMP-9 were measured by enzyme- linked immunosorbent assay （ELISA）. The levels of serum ET-1, MCP-1 and MMP-9 in different groups were com- pared. Results The serum levels of ET-1, MCP-1 and MMP-9 in AMI, UAP and SAP groups were significantly higher than those in the control group （ t = 5.12,5.35,5.15,4.22,4.65,4.54,3.12,3.65,3.54, all P 〈 0.05 ）. Compared with SAP group,the levels of ET-1, MCP-1 and MMP-9 were increased in AMI and UAP groups （t = 4.32,4. 15, 4. 52,3.54,3.23,3.51, all P 〈 0.05 ）. Compared with UAP group, the levels of ET-1, MCP-1 and MMP-9 were increased in AMI groups（t =3.78,3.96,3.56,all P〈0.05）. Conclusion Serum ET-1 ,MCP-1 and MMP-9 may be the markers of coronary atherosclerosis and involved in the process of CHD. The levels of serum ET-1, MCP-1 and MMP-9 are correlated with the severity of CHD.