怀山药多糖对大鼠胃溃疡的疗效及胃组织表皮生长因子水平的影响

目的：观察怀山药多糖对胃溃疡大鼠的治疗作用，研究怀山药多糖对胃溃疡大鼠胃组织表皮生长因子（EGF）水平的影响。方法将50只大鼠随机分为五组，分别为空白组（A组），模型组（B组），怀山药多糖组（C组），替普瑞酮组（D组）及怀山药多糖＋替普瑞酮组（E组）等。观察并比较各组胃溃疡的愈合情况，取胃组织检测并比较EGF水平。结果（1）C组的溃疡指数显著低于B组（P＜0．01）。（2）C组胃组织EGF水平显著高于A组（P＜0．05），与D组差异无统计学意义（P＞0．05）。结论怀山药多糖具有良好的胃黏膜保护作用，其机制可能与上调胃溃疡大鼠胃组织EGF水平有关。

The effect of Dioscorea opposita polysaccharide in the treatment of rats with gastric ulcer and its influence on the level of EGF in gastric ulcer tissues

Objective To observe the therapeutic effect of Dioscorea opposita polysaccharide on gastric ulcer in rats,and to investigate the effects of Dioscorea opposita polysaccharide on level of epidermal growth factor （ EGF） in stomach tissues .Methods 50 rats were randomly divided into five groups [ A group （ normal control group ） , B group（model group）,C group（Dioscorea opposita polysaccharide group ）,D group（teprenone group）].The healing condition of gastric ulcer and EGF level were observed and compared .Results （1）The ulcer index of C group was obviously reduced compared with B group （P〈0.01）.（2）Between C group and A group,the significant difference existed in the level of EGF（P〈0.05）,while the difference was not statistically significant between C group and D group（P〉0.05）.Conclusion Dioscorea opposita polysaccharide has protective effects for gastric mucosa .The mechanism of protection may be related to promote synthesis of EGF .