参松养心胶囊对持续性心房颤动患者复律后血浆超敏C反应蛋白和N-末端脑钠肽前体水平的影响

目的 探讨参松养心胶囊对持续性心房颤动（简称房颤）患者复律后血浆超敏C反应蛋白（hs-CRP）和N-末端脑钠肽前体（NT-proBNP）的影响.方法 152例持续性房颤患者按照数字表法随机分为两组各76例,两组均进行房颤复律.随访12个月.测定治疗前后血浆hs-CRP和NT-proBNP.结果 所有房颤患者经复律后转复为窦性心律,在12个月的随访中,观察组有2例患者房颤复发,对照组9例复发,两组差异有统计学意义（Х^2=5.28,P＜0.05）.两组hs-CRP和NT-proBNP在治疗后均明显降低（t=7.270、3.601、8.118、3.006,P＜0.05,P＜0.01）,并且观察组降低程度更加明显（t=4.720、2.914,均P＜0.05）.结论 参松养心胶囊可以明显减轻持续性房颤患者复律后血浆hs-CRP和NT-proBNP的表达.

Influence of Shensongyangxin capsule on plasma hs-CRP and NT-proBNP in patients with persistent atrial fibrillation after cardioversion

Objective To explore the influence of Shensongyangxin capsule on plasma high-sensitivity C-reactive protein（hs-CRP） and N-terminal pro-brain natriuretic peptide（NT-proBNP） in patients with persistent atrial fibrillation after cardioversion.Methods 152 patients with persistent atrial fibrillation were randomly divided into the observation group（76 cases）and the control group （76 cases）.All patients were conducted atrial cardioversion.The patients were followed up for 12 months.The plasma hs-CRP and NT-proBNP were measured before and after treatment.Results All patients with atrial fibrillation were cardioversed to sinus rhythm after cardioversion.During 12 months of follow-up,in the observation group 2 patients had recurrence of atrial fibrillation and in the control group,nine cases of recurrence,the difference between the two groups was significant （Х^2 =5.28,P 〈 0.05）.After treatment,the plasma hs-CRP and NT-proBNP in the two groups were significantly decreased（t =7.270,3.601,8.118,3.006,P 〈 0.05,P 〈 0.01）,and those in the observation group were significantly lower than control group （t =4.720,2.914,all P 〈 0.05）.Conclusion Shensongyangxin capsule can significantly reduce plasma hs-CRP and NT-proBNP in patients with persistent atrial fibrillation after cardioversion.