半量曲普瑞林用于子宫内膜异位症术后的临床分析

目的：分析子宫内膜异位症术后应用半量曲普瑞林的疗效及安全性。方法86例子宫内膜异位症患者按照数字表法随机分为两组，观察组43例，对照组43例，所有患者采用腹腔镜治疗，术后观察组予半量曲普瑞林治疗、对照组予全量曲普瑞林治疗，共治疗6个月。测定治疗前后血清糖类抗原125（CA125）和肿瘤坏死因子-α（ TNF-α）。结果两组患者均顺利完成手术。治疗后对照组总有效率为97．7％，观察组总有效率为95．3％，两组差异无统计学意义（χ2＝1．46，P＞0．05）。手术后随访1年，对照组复发5例，复发率为11．6％；观察组复发4例，复发率为9．3％；两组差异无统计学意义（χ2＝0．92，P＞0．05）。两组患者治疗后血清CA125和TNF-α均有明显降低，但两组比较差异均无统计学意义（t＝0．773、0．131，均P＞0．05）。治疗期间对照组有15例患者发生不良反应，发生率为34．9％；观察组有5例发生不良反应，发生率为11．6％；观察组不良反应明显少于对照组（χ2＝6．78，P＜0．05）。结论子宫内膜异位症患者术后采用半量曲普瑞林治疗与全量治疗效果相当，并且不良反应少。

Clinical analysis of half amount triptorelin in patients with endometriosis after operation

Objective To analyze half amount triptorelin in patients with endometriosis after application . Methods According to digifal table ,86 patients with endometriosis were randomly divided into the two groups：the observation group（43 cases）and the control group（43 cases）.All patients were treated with laparoscopy .The patients in the observation group were treated through half amount triptorelin ,while the control group was treated through whole amount triptorelin .They were treated for six months .Serum carbohydrate antigen 125 （ CA125 ） and tumor necrosis factor-α（ TNF-α） were measured before and after treatment .Results The groups of patients were successfully operated.The total effective rates in the control group were 97.7%in the control group and 95.3%in the observation group,there was no significant difference （χ2 =1.46,P〉0.05）.1-year follow-up after surgery,the control group had 5 cases of recurrence ,the recurrence rate was 11.6%,the observation group had 4 cases of recurrence ,the recurrence rate was 9.3%,there was no significant difference （χ2 =0.92,P〉0.05）.After treatment,serum CA125 and TNF-αwere significantly lowered,but levels of serum CA125 and TNF-αafter treatment had no significant difference （t=0.773,0.131,P〉0.05）.During treatment,the control group had 15 cases of adverse reactions ,the rate was 34.9%and the observation group had 5 cases of adverse reactions,the rate was 11.6%.The observation group should be significantly less than the control group （χ2 =6.78,P〈0.05）.Conclusion Half amount triptorelin had the quite effect with whole amout and fewer adverse reactions .