头孢曲松治疗小儿支气管肺炎疗效观察及对患儿血清炎性因子水平的影响

目的 探讨头孢曲松治疗小儿支气管肺炎疗效及对患儿血清炎性因子水平的影响.方法 将85例小儿支气管肺炎患儿按照随机数字表分为观察组43例以及对照组42例,两组患儿均采用氨溴索治疗,对照组在此基础上联合应用青霉素（20万u/kg,2次/d）,观察组在此基础上采用头孢曲松（20 mg/kg,1次/d）治疗,7d为1个疗程.对比分析两组患儿临床疗效、症状缓解时间及治疗前、治疗后1d、3d、5d、7d超敏C反应蛋白（CRP）、白细胞介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平.结果 观察组总有效率为96.97％,对照组为75.00％,两组总有效率差异有统计学意义（x2=5.236,P=0.000.）.观察组治疗后各症状评分显著低于对照组,差异有统计学意义（t =3.425、3.622、3.712、3.812,均P＜0.05）.观察组治疗后3dCRP（4.28±1.07） mmol/L、IL-6（7.21±2.07） mmol/L、TNF-α（15.36±3.78） mmol/L水平显著低于治疗前及对照组同一时间（7.63±1.28） mmol/L、（12.31±2.42） mmol/L、（22.12±7.55）mmol/L,而对照组治疗5d后CRP、IL-6、TNF-α水平低于治疗前,差异有统计学意义（P＜0.05）.结论 头孢曲松能有效缓解小儿肺炎症状,快速降低炎性因子水平,提高患儿临床治疗效果.

Analysis of ceftriaxone efficacy in children with bronchial pneumonia and inflammation factors

Objective To investigate the effects of the levels of inflammatory cytokines on children with bronchial pneumonia ceftriaxone.Methods 85 cases of children with bronchial pneumonia were randomly divided into observation group （n =43） and control group （n =42）.Two groups were treated on the basis of penicillin （200 000U/kg,2 times/d）,the observation group ceftriaxone （20mg/kg,1 times/d） treatment on the basis of the times,7d course of treatment.The clinical efficacy of two groups were compared.The levels of C-reactive protein （CRP）,interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） before and after treatment,1d,3d,5d,7d were analyzed.Results The total effective rate of observation group was 96.97％,the control group was 75.00％,the total efficiency of the two groups had significant difference （x2 =5.236,P =0.000）.After treatment,fever,cough,wheezing,rales symptom score decreased significantly compared with pre-treatment,post-treatment observation group political scores were significantly lower than those of the control group,the difference was statistically significant （t =3.425,3.622,3.712,3.812,P ＜ 0.05）.The levels of C RP （4.28 ± 1.07） mmol/L,IL-6 （7.21 ± 2.07） mmol/L,TNF-α（15.36 ± 3.78） mmol/L of observation group after treatment were significantly lower than those of before treatment and control groups at the same time,while the control group after treatment 5d CRP,IL-6,TNF-α levels lower than before treatment,the difference was statistically significance （P ＜ 0.05）.Conclusion Ceftriaxone can effectively relieve symptoms of pneumonia in children,quickly reduce the levels of inflammatory factors,improve clinical outcomes in children.