非洛地平联合厄贝沙坦对高血压患者血压控制及颈动脉内-中膜厚度的影响

目的：探讨非洛地平联合厄贝沙坦在高血压治疗中的临床疗效以及其对动脉粥样硬化的缓解效果。方法将100例高血压患者采用随机数字表分为观察组和对照组，每组50例。对照组采用厄贝沙坦治疗，观察组在对照组的基础上采用非洛地平治疗，比较两组疗效、血压控制水平和颈动脉内-中膜厚度的变化。结果观察组总有效率为90．0％，显著高于对照组的72．0％（χ2＝3．85，P＜0．05）。观察组治疗后的收缩压、舒张压均显著低于对照组（ t＝4．21、5．05，均P＜0．05）。观察组治疗后的颈动脉斑块的大小、厚度显著低小于对照组（t＝1．98、5．05，均P＜0．05）。结论非洛地平联合厄贝沙坦能够显著提高高血压患者的治疗效果，改善血压控制水平，延缓动脉粥样硬化的进程。

Effect of felodipine combined with irbesartan on blood pressure control and carotid artery intima-media thickness in hypertensive patients

Objective To investigate the clinical efficacy of felodipine combined with irbesartan in the treat-ment of hypertension and its effect on atherosclerosis in remission .Methods 100 patients with hypertension were divided into the observation group and the control group .The control group was given the felodipine treatment ,the obser vation group was given felodipine treatment based on the control group .The treatment effect ,changes of blood control and carotid artery intima-media thickness were compared between the two groups .Results The total effective rate of the observation group was 90.0%,which was significantly higher than 72% of the control group （χ2 =3.85,P〈0.05）.After treatment,the systolic pressure,diastolic pressure of the observation group were significantly lower than those in the control group（t=4.21,5.05,all P〈0.05）.After treatment,the size,thickness of carotid artery plaque of the observation group were significantly lower than those of the control group （t =1.98,5.05,all P 〈0.05）. Conclusion Felodipine combined with irbesartan can significantly improve the therapeutic effect of hypertensive patients,and can improve the control of blood pressure ,slow the progression of atherosclerosis .