神经节苷脂联合高压氧治疗新生儿缺氧缺血脑病的临床研究

目的：探讨神经节苷脂联合高压氧治疗新生儿缺氧缺血性脑病（ HIE）的临床疗效。方法将HIE患儿68例随机分为四组：对照组、神经节苷脂组、高压氧组和联合治疗组，每组17例。对照组采用常规治疗，神经节苷脂组和高压氧组在常规治疗基础上，加以神经节苷脂或高压氧舱治疗，联合治疗组在常规治疗基础上，采用神经节苷脂和高压氧舱联合治疗。比较各组患儿的治疗效果。结果联合治疗组的总有效率显著高于对照组（χ2＝5．885，P＜0．05），神经节苷脂组和高压氧组总有效率与对照组相比略有提高，但无统计学意义。各治疗组患儿在治疗10 d和20 d的NBNA评分均显著高于对照组（10 d：t＝9．451，P＜0．05；20 d：t＝12．83，P＜0．05），且联合治疗组显著高于单用神经节苷脂和高压氧舱组（10 d：t＝3．755，P＜0．05；20 d：t＝3．533，P＜0．05）。结论神经节苷脂和高压氧舱两者联合用于HIE具有协同增效作用，是临床治疗HIE的理想措施之一。

Clinical study of gangliosides combined with hyperbaric oxygen therapy on neonatal ischemic encephalopathy

Objective To investigate the therapeutic effect of gangliosides combined with hyperbaric oxygen therapy（ HBO） in treatment of neonatal ischemic encephalopathy （ HIE） .Methods 68 patients with HIE were ran-domly divided into 4 groups（n=17）：the control group,gangliosides group,HBO group and combined group .The con-trol group received conventional therapy ,gangliosides and HBO group received gangliosides and HBO therapy respec-tively and combined group received both gangliosides and HBO therapy .The therapeutic effects were evaluated 10d and 20d after treatment.Results Compared with the control group ,the total efficiency was significantly increased in the combined group（χ2 =5.885,P〈0.05）,but not in gangliosides and HBO group .Moreover,all treatment groups significantly elevated the neonatal behavioral neurological assessment （NBNA）in day 10 and 20,and there were signif-icant differences between the combined group and gangliosides or HBO group （ t=3.755,P〈0.05;t=3.533,P〈0.05）.Conclusion The use of gangliosides combined with HBO has synergistic interaction in treatment of HIE , which is worthy of clinical application .