米索前列醇用于腹腔镜下子宫肌瘤剔除术止血的效果

目的：探讨腹腔镜下子宫肌瘤剔除术应用米索前列醇止血的效果。方法将100例腹腔镜下子宫肌瘤剔除术的育龄期妇女按照抽签方法随机均分为对照组与观察组，每组各为50例。对照组在手术麻醉后给予静脉滴注缩宫素注射液20 IU；观察组术前8 h左右阴道后穹窿放置米索前列醇片400μg。比较两组手术时间、术中出血量、住院时间、排气时间、术后随访及不良反应发生情况等。结果（1）对照组手术时间、术中出血量、住院时间及排气时间分别为（75．69±12．90）min、（110．37±43．92）mL、（7．89±0．29）d及（26.09±1．22）h，均显著大于观察组[分别为（61．87±11．06）min、（72．28±34．52）mL、（6．38±0．33）d及（21．73±1．09）h]（t＝10．929、15．663、4．262、3．977，P＝0．008、0．006、0．037、0．039）；（2）对照组随访时间、不良反应发生率分别为（10．22±0．90）个月、24．00％（12/50），观察组分别为（11．28±0．89）个月、10．00％（5/50），两组随访时间差异无统计学意义（t＝0．189，P＝0．382），但不良反应发生率差异具有统计学意义（t＝6.722，P＝0．015）。结论腹腔镜下子宫肌瘤剔除术应用米索前列醇止血效果显著，值得在临床推广应用。

Analysis of laparoscopic myomectomy misoprostol hemostatic effect

Objective To explore hemostatic effect of laparoscopic uterine myomectomy treated with misopr-ostol .Methods Women of childbearing age in 100 cases of laparoscopic were divided randomly according to the draw method as the control group and observation group ,each group included 50 cases.The control group were given no treatment,the observation group were given 400μg fornix misoprostol tablets about 8 hours before surgery.The op-eration time,amount of bleeding , the hospitalization time ,exhaust time,postoperative follow-up and the incidence of adverse reactions were compared between the two groups .Results （1） Operation time,amount of bleeding ,hospitali-zation time and exhaust time of the control group were （75.69 ±12.90）min,（110.37 ±43.92）mL,（7.89 ±0.29）d and （26.09 ±1.22）h,were significantly greater than those of the observation group [（61.87 ±11.06）respectively min,（72.28 ±34.52）mL,（6.38 ±0.33）d and （21.73 ±1.09）h], the difference was statistically significant （t=10.929,15.663,4.262,3.977,P=0.008,0.006,0.037,0.039）;（2） Follow-up time,adverse reaction rates of control group were （10.22 ±0.90）months,24%（12/50）,the observation group were （11.28 ±0.89）months,10%（5/50）,there were no statistically significant differences between the two groups during the follow -up period （ t =0.189,P=0.382）,but the incidence of adverse reactions compared ,the difference was statistically significant （t=6.722,P=0.015）.Conclusion Hemostatic effect of laparoscopic uterine myomectomy treated with misoprostol was significant ,which is worth to be promoted and applied in clinic .