噻托溴铵对稳定期慢性阻塞性肺疾病患者呼吸功能及生活质量的影响

目的：探讨噻托溴铵在稳定期COPD患者治疗中的价值。方法80例稳定期COPD患者按随机数字表法分为观察组40例和对照组40例，对照组采用沙美特罗/丙酸氟替卡松治疗，观察组在对照组的基础上加用噻托溴铵治疗，比较两组疗效。结果两组治疗前呼吸困难评分、肺功能指标（ FEV1、FEV1/FVC）和生活质量评分差异均无统计学意义（t＝0．34、0．85、0．93、0．73，均P＜0．05）。观察组治疗后呼吸困难评分显著低于对照组，肺功能指标（ FEV1、FEV1/FVC）和生活质量评分均显著高于对照组（ t＝1．98、13．75、9．51、5.87，均P＜0．05）。两组均无严重不良反应出现。结论噻托溴铵能够显著改善稳定期COPD患者的肺功能，减轻呼吸困难，提高运动耐力。

Influence of tiotropium bromide on respiratory function and life quality in COPD patients at stable stage

Objective To investigate the effect of tiotropium bromide in the treatment of chronic obstructive pulmonary disease （ COPD） patients at stable stage .Methods 80 COPD patients at stable stage were randomly divid-ed into the observation group and the control group ,40 cases in each group .The control group was given salmeterol/fluticasone propionate ,the observation group was given tiotropium bromide based on the control group .The clinical effects were compared between two groups .Results Before treatment ,the dyspnea score ,lung function index FEV 1 , FEV1/FVC and life quality score between the two groups had no statistically significant differences （t=0.34,0.85, 0.93,0.73,all P〈0.05）.After treatment,the dyspnea score in the observation group was significantly lower than that in the control group ,and the lung function parameters of FEV 1 ,FEV1/FVC and life quality score in observation group were significantly higher than those in the control group （t=1.98,13.75,9.51,5.87,all P〈0.05）.No serious adverse reaction occurred in both two groups .Conclusion Tiotropium bromide in the treatment of COPD patients at stable stage can obviously improve the lung function ,relieve dyspnea and improve exercise tolerance .