盐酸利托君与硫酸镁治疗先兆早产的疗效比较及对胎儿纤维连接蛋白的影响

目的：探讨盐酸利托君与硫酸镁治疗先兆早产的疗效及对胎儿纤维连接蛋白（ fFN）的影响。方法选择368例先兆早产产妇，按照随机-平行对照法分为盐酸利托君治疗组（简称观察组）以及硫酸镁治疗组（简称对照组），观察两组疗效、胎儿纤维连接蛋白阳性率并评价其安全性。结果与对照组比较，观察组药物起效时间、缩短明显，妊娠延长天数、治疗成功比例增加明显，差异均有统计学意义（ t＝103．4、9．6，χ2＝12．0，均P＜0．05）。治疗前，两组fFN阳性率差异无统计学意义（χ2＝0．4，P＞0.05），治疗后观察组fFN阳性率为28．26％，对照组为42．39％，两组差异有统计学意义（χ2＝8．0，P＜0.05）。观察组不良反应发生率（19.57％）显著低于对照组（29．35％）（χ2＝4．8，P＜0．05）。结论盐酸利托君治疗先兆早产疗效较佳，可缩短药物起效时间，延长妊娠天数，而且可显著降低fFN阳性率，具有较好的安全性。

Curative effect between ritodrine hydrochloride and magnesium sulfate treated with threatened premature labor and its effect to fetal fibronectin

Objective To discuss curative effect between ritodrine hydrochloride and magnesium sulfate treated with threatened premature labor and its effect to fetal fibronectin .Methods 368 cases threatened premature labor puerperants were selected and randomly divided into the ritodrine hydrochloride treatment group （ short for obser-vation group） and magnesium sulfate treatment group （short for control group）,The two group puerperants′curative effect,changes of fetal fibronectin positive rate and safety evaluation were observed .Results Compared with the con-trol group,the observation group′s medicine effect time ,treatment failure proportion obviously decreased;prolongation pregnancy days,treatment success proportion obviously increased ,the differences all had statistical significances （t=103.4,9.6,χ2 =12.0,all P〈0.05）.Before the treatment,compared the two groups′fFN positive rates,the differ-ences hadn′t statistical significances（χ2 =0.4,P〉0.05）;after the treatment,the observation group′s fFN positive rates was 28.26%,wich of the control group was 42.39%,compared the two groups′fFN positive rates,the observa-tion group obviously decreased ,the differences had statistical significances （χ2 =8.0,P 〈0.05）.The observation group′s untoward effect rate was 1 9 .5 7%, which was lower than that of the control group （χ2 =4 .8 , P〈0 .0 5 ） .Conclusion Ritodrine hydrochloride treated with threatened premature labor not only can get good treatment effect , shorten medicine effect time ,prolong pregnancy days;but also can obviously decrease fetal fibronectin positive rate , which has good safety ,and is suitable for clinical application .