丁苯肽联合尼莫地平治疗血管性认知功能障碍疗效观察

目的 探讨丁苯肽联合尼莫地平治疗血管性认知功能障碍的临床效果.方法 160例血管性认知障碍患者,根据治疗方法分为对照组和观察组各80例,对照组单纯应用尼莫地平治疗,观察组丁苯肽联合尼莫地平治疗,分析比较两组治疗效果,并评估认知功能.结果 观察组显效率为58.75％ （47/80）,高于对照组的45.00％（36/80）（P=0.03）;观察组治疗后MoCA评分为（24.83 ±9.48）分,高于对照组的（21.64±9.52）分（P=0.04）.观察组治疗后ADL评分（58.31±11.27）分,高于对照组的（53.28±10.32）分（P=0.04）;观察组治疗后定向力、视空间与执行功能、延迟回忆和注意力,均高于对照组治疗后（P=0.03,0.02,0.04,0.02）.结论 丁苯肽联合尼莫地平治疗血管性认知功能障碍临床效果较好.

Observation of the effect of butylphthalide combined with nimodipine in the treatment of vascular cognitive impairment

Objective To investigate the effect of butylphthalide combined with nimodipine in the treatment of vascular cognitive impairment.Methods 160 patients with vascular cognitive impairment were divided into the control group and the observation group according to treatment methods,80 cases in each group.The control group was treated with nimodipine,and the observation group was given butylphthalide combined with nimodipine treatment.The therapeutic effect and cognitive function were compared.Results The obvious effective rate of the observation group was 58.75 ％ （47/80）,which was significantly higher than that of control group 45 ％ （36/80） （P =0.03）.After treatment,MoCA score of the observation group was （24.83 ± 9.48）,which was significantly higher than that of the control group（21.64 ±9.52） （P =0.04）.ADL score of the observation group was（58.31 ± 11.27）,which was significantly higher than（53.28 ± 10.32） of the control group （P =0.04）.After treatment,directional force,visual spatial and executive function,delayed memory and attention of the observation group were higher than those of the control group （P =0.03,0.02,0.04,0.02）.Conclusion Butylphthalide combined with nimodipine in the treatment of patients with vascular cognitive impairment has good effect.