成年人活动性肺结核患者血清腺苷脱氨酶和降钙素原联合检测的临床意义

目的：探讨成年人活动性肺结核患者血清腺苷脱氨酶（ ADA）和降钙素原（ PCT）检测的临床意义。方法选择81例活动性肺结核患者作为A组、非结核性肺部感染患者43例作为B组、肺癌患者27例作为C组。测定三组患者血清ADA和PCT，并对结核患者进行6个月的抗痨治疗。结果 ADA水平：A组与B、C组差异均有统计学意义（t＝12．983、10．630，均P＜0．01），B组与C组差异无统计学意义（t＝0．144，P＝0．885）；PCT水平：A组与B组差异有统计学意义（t＝16．775，P＜0．01），A组与C组差异无统计学意义（t＝1．571，P＝0．119），B组与C组差异有统计学意义（t＝11．235，P＜0．01）。81例肺结核患者经治疗后缓解67例，无缓解14例；缓解组患者血清ADA和PCT水平均明显低于无缓解组患者（ t＝3．087、3．404，均P＜0.05）。结论血清ADA可以作为活动性肺结核的诊断指标，ADA和PCT联合测定可以判断活动性肺结核的预后。

The clinical significance of the detection of adenosine deaminase combined with procalcitonin in adult patients with active pulmonary tuberculosis

Objective To explore the clinical significance of the adenosine deaminase （ ADA） and the pro-calcitonin（PCT） in adult patients with active pulmonary tuberculosis .Methods 81 patients with active pulmonary tuberculosis were enrolled into A group ,43 patients with non-tuberculous lung infection were enrolled into B group and 27 patients with lung cancer were enrolled into C group .Serum ADA and PCT were detected .Tuberculosis patients were treated for 6 months of anti-tuberculosis treatment .Results There was a significant difference between group A and B or C group about ADA （t=12.983,10.630,all P〈0.01）,B and C groups showed no significant difference （t=0.144,P=0.885）.Group A PCT compared with group B were significantly different （t=16.775,P〈0.01）, the A group and C group showed no significant difference （t=1.571,P=0.119）,group B compared with group C were significantly different （t=11.235,P〈0.01）.Tuberculosis treatment remission in 67 cases,no relief in 14 ca-ses.The levels of serum ADA and PCT in remission were significantly lower than in patients with no remission group （t=3.087,3.404,all P〈0.05）.Conclusion The serum ADA can be used as diagnostic indicators of active tuber-culosis,ADA and PCT joint determination can determine the prognosis of active tuberculosis .