C反应蛋白与老年患者髋部术后谵妄的关系研究

目的：研究CRP与老年患者髋部手术后出现谵妄的关系，探讨谵妄发生、发展的可能机制。方法将髋部骨折术后的老年患者共186例纳入研究，术后24 h内依据重症监护室患者意识模糊评估结果分为谵妄组及非谵妄组，检测并比较两组血清CRP和降钙素原水平。结果谵妄组、非谵妄组CRP分别为（207±86）mg/L、（87±42）mg/L，两组差异有统计学意义（t＝2．427，P＜0．01）；谵妄组、非谵妄组降钙素原水平分别为（0．32±0．11）μg/L、（0．27±0．13）μg/L，两组差异无统计学意义（ t＝0．347，P＞0．05）。结论 CRP可能与谵妄状态相关；非全身性感染性炎性反应可能参与谵妄的发生、发展。

Research on the relationship between C reactive protein and postoperative delirium of elderly patients after hip fracture

Objective To study the relationship between C reactive protein （ CRP） and postoperative deliri-um of elderly patients after hip fracture , and to explore the possible mechanism of delirium .Methods A total of 186 elderly patients with hip fracture who received operation were included in the study .24h after operation,according to the patients＆#39;awareness of ICU fuzzy evaluation method ,the patients were divided into the delirium group and non delirium group .The levels of CRP and procalcitonin were detected and compared .Results The CRP levels in the de-lirium group and non delirium group were （207 ±86）mg/L,（87 ±42）mg/L,there was significant difference between two groups （t =2.427,P 〈0.01）.The procalcitonin levels in the delirium group and non delirium group were （0.32 ±0.11）μg/L,（0.27 ±0.13）μg/L,the difference between the two groups was not significant （t=0.347,P〉0.05）.Conclusion CRP may be related with delirium.Inflammatory response without systemic infection may be one of the mechanisms of delirium .