序贯疗法与四联疗法治疗幽门螺杆菌阳性消化性溃疡的疗效比较

目的比较序贯疗法与四联疗法治疗幽门螺杆菌（Hp）阳性消化性溃疡疗效及Hp根除率。方法采用前瞻性的方法，将120例消化性溃疡患者按单双号随机分为治疗组与对照组各60例，治疗组采用序贯疗法，对照组采用四联疗法。结果治疗组与对照组总有效率分别为86．7％和91．7％，两组比较差异无统计学意义（P〉0．05）。经检测，治疗组Hp根除率90．0％，对照组Hp根除率85．0％，两组Hp根除率差异无统计学意义（P〉0．05）。结论序贯疗法治疗消化性溃疡的有效率和Hp根除率较四联疗法无明显差异，可作为Hp感染初治患者的一线方案。

Comparison of sequential therapy versus quadruple therapy for Helicobacter pylori related peptic ulcer

Objective To compare the sequential therapy and quadruple therapy for Helicobacter pylori （ H. pyl0ri） eradicate rate and the effective rate for the treatment of H. pylori related peptic ulcer. Methods Prespec- tively, 120 patients with H. pylori related peptic ulcer were randomly divided into the treatment group and the control group （ n = 60）. The treatment group was received the ten days sequential therapy and the control group received the quadruple therapy. Results There were no significant differences in the effective rate for the treatment of H. pylori related peptic ulcer （ 86.7% % vs 91.7% , P 〉 0.05 ） and the eradication rate of H. pylori infection （ 90.0% vs 85.0% ,P 〉 0, 05） between the treatment group and the control group. Conclusion Ten days sequential therapy is an effective therapy for the treatment of H. pylori related peptic ulcer and H. pylori eradication ,which can be used as an initial treatment of patients with H. pylori infection.