冠心病心力衰竭患者脑钠肽、高敏C反应蛋白水平变化

目的探讨冠心病心力衰竭患者血浆脑钠肽（BNP）、高敏C反应蛋白（hs-CRP）水平变化的意义。方法选择冠心病心力衰竭患者160例为观察组，健康人群200例为对照组，对BNP和hs-CRP进行检测分析。结果观察组BNP和hs—CRP分别为（481．5±57．8）pg／mL和（12．4±2．9）mg／mL，均高于对照组（41．2±9．6）pg／mL）和（3．8±1．1）mg／L]，差异有统计学意义（t=13．17，5．28，均P〈0．05）；观察组左室射血分数（LVEF）为（41．9±6．3）％，低于对照组的（60．2±8．4）％，差异具有统计学意义（t=7．94，P〈0．05）；随心功能（Ⅰ级、Ⅱ级、Ⅲ级和Ⅳ级）变化BNP和hs-CRP均随着分级的增加逐渐增高，差异均具有统计学意义（t=5．20、10．11、12．42、4．18、5．02、3．98，均P〈0．05）。经Logistic分析，血清BNP和hs—CRP与冠心病心力衰竭相关。结论冠心病心力衰竭患者心功能与BNP和hs—CRP相关，随着分级的增加BNP和hs．CRP均逐渐增高。

The change of BNP and hs-CRP levels in coronary heart disease patients with heart failure

Objective To investigate the relationship between coronary heart disease patients with heart failure and natriuretic peptide （BNP） and c-reactive protein（ hs-CRP）, and provide the clinical basis. Methods 160 coronary heart disease patients with heart failure were selected as the observation group, and 200 health individuals as the control group. The BNP and hs-CRP with heart failure were analyzed. Results BNP and hs-CRP of the observation group were （481.5 ± 57.8 ）pg/mL and （12.4 ± 2.9）mg/L, which were higher than that of the control group （41.2 ± 9.6 ） pg/L vs （3.8 ± 1.1 ） mg/L ], the difference was statistically significant （ t = 13.17,5.28, all P 〈 0.05 ） ; Left ventricular ejection fraction（LVEF） of the observation group was （all. 9 ± 6.3 ） %, lower than that of the control group （60.2 ± 8.4） %, the difference was statistically significant（ P 〈 0.05 ） ; BNP and hs-CRP of grade Ⅰ , Ⅱ, Ⅲ and Ⅳ increased with the grade, the differences were statistically significant （ t = 5.20,10. 11,12.42,4. 18,5.02,3.98, all P 〈 0. 05 ） ; By Logistic analysis, serum BNP and hs-CRP were associated with heart failure of coronary heart disease. Conclusion Coronary heart disease patients with heart failure cardiac function were associated with BNP and hs- CRP, and with grade were gradually increasing that BNP and hs-CRP increased.