| Fas及Fas配体在盘状红斑狼疮皮损中的表达 |
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| 引用本文： | 张敏,李俸媛,等.Fas及Fas配体在盘状红斑狼疮皮损中的表达[J].华西医科大学学报,2001,32(4):513-515. |
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| 作者姓名： | 张敏 李俸媛 |
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| 作者单位： | [1]华西医科大学附属第一医院皮肤科，成都610041 [2]附属第一医院病理科 |
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| 摘 要： | 目的 研究细胞凋亡与红斑狼疮发病的关系。方法 采用免疫组化法检测了30例盘状红斑狼疮（DLE）患者皮损及5例正常对照皮肤Fas及Fas配体（FasL）的表达。结果 DLE皮损中表皮角质形成细胞、真皮血管周围及部分皮肤附属器周围浸润淋巴细胞可见较多的Fas、FasL阳性表达。少数毛囊、汗管可见Fas阳性表达。正常对照的Fas及FasL表达弱阳性或阴性。结论 Fas、FasL途径诱导的细胞凋亡可能与红斑狼疮发病有关。
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| 关 键 词： | 盘状红斑狼疮 Fas Fas配体 细胞凋亡 免疫组化法 病理 |
Expression of Fas and Fas ligand in lesions of patients with discoid lupus erythematosus] |
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| M Zhang,Y Zhang,L Wang,F Li.Expression of Fas and Fas ligand in lesions of patients with discoid lupus erythematosus][J].Journal of West China University of Medical Sciences,2001,32(4):513-515. |
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| Authors: | M Zhang Y Zhang L Wang F Li |
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| Institution: | Department of Dermatology, First Affiliated Hospital, WCUMS, Chengdu 610041, China. |
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| Abstract: | OBJECTIVE: To study the relation of apoptosis and pathogenesis of lupus erythematosus. METHODS: Expressions of Fas and Fas ligand(FasL) were detected in 30 lesions of discoid lupus erythematosus(DLE) and 5 skin specimens from healthy controls by immunohistochemical staining. RESULTS: Fas and FasL were positively expressed in most epidermal keratinocytes, infiltrating lymphocytes around blood vessels and appendages, and Fas was positively expressed in a few sweat ducts and hair follicles. Fas and FasL expressions were weakly positive or negative in healthy controls. CONCLUSION: Apoptosis induced by Fas, FasL pathway may be related to the pathogenesis of lupus erythematosus. |
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