Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury |
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| Authors: | Li Zhang Weidong Gan Guoyao An |
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| Affiliation: | Li Zhang (School of Traumatology and Orthopedics, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China);Weidong Gan (School of Traumatology and Orthopedics, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China);Guoyao An (School of Traumatology and Orthopedics, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China); |
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| Abstract: | Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone IIa promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone IIa, compared with positive control Danshen injection. |
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| Keywords: | Tanshinone IIa Danshen spinal ischemia/reperfusion injury heat shock protein 70 Bcl-2 Bax cell apoptosis Chinese medicine neural regeneration |
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