| 人血浆中硝苯地平的气相色谱法测定及药代动力学研究 |
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| 引用本文： | 吴静,张正行,王玉. 人血浆中硝苯地平的气相色谱法测定及药代动力学研究[J]. 药学学报, 1997, 32(2): 147-150 |
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| 作者姓名： | 吴静 张正行 王玉 |
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| 作者单位： | 中国药科大学药物分析研究室(吴静)，南京化工大学应用化学系(张正行)，江苏省医药工业研究所(王玉) |
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| 摘 要： | 人血浆中硝苯地平的气相色谱法测定及药代动力学研究吴静张正行王玉（中国药科大学药物分析研究室，南京２１０００９）硝苯地平的血药浓度较低，为了合理地指导临床用药，进行药代动力学研究，必需建立灵敏的体内分析方法。硝苯地平的体内测定方法有同位素标记法［...
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| 关 键 词： | 硝苯地平 气相色谱法 药代动力学 |
| 收稿时间： | 1996-04-29 |
DETERMINATION OF NIFEDIPINE IN HUMAN PLASMA BY GAS CHROMATOGRAPHY AND ITS PHARMACOKINETIC STUDY |
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| J Wu,ZX Zhang and Y Wang. DETERMINATION OF NIFEDIPINE IN HUMAN PLASMA BY GAS CHROMATOGRAPHY AND ITS PHARMACOKINETIC STUDY[J]. Acta pharmaceutica Sinica, 1997, 32(2): 147-150 |
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| Authors: | J Wu ZX Zhang Y Wang |
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| Affiliation: | Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009. |
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| Abstract: | A gas chromatographic method for the determination of nifedipine in human plasma is presented. Nifedipine was extracted into toluene and diazepam was used as the internal standard. Chromatography was performed on an OV-101 fused-silica column by splitless injection with an electron capture detector. The minimal detectable concentration in plasma was 1 ng.ml-1. The standard curve was linear in the range 2-150 ng.ml-1 (gamma = 0.9988). The method has been applied to pharmacokinetic study. |
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| Keywords: | Nifedipine Gas chromatography Pharmacokinetics |
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