| 缺铁大鼠耳蜗组织铁降低对耳蜗听功能的影响 |
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| 引用本文： | 周义德,沈小华,张青,李兆基. 缺铁大鼠耳蜗组织铁降低对耳蜗听功能的影响[J]. 中国组织工程研究与临床康复, 2001, 5(5): 63 |
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| 作者姓名： | 周义德 沈小华 张青 李兆基 |
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| 作者单位： | 解放军第二军医大学长海医院, |
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| 摘 要： | 目的检测缺铁大鼠耳蜗组织微量元素含量及听阈改变。方法复制缺铁大鼠模型,测大鼠客观听阈改变,用原子吸收光谱法测定大鼠血清微量元素及耳蜗组织微量元素含量。结果缺铁组和正常组大鼠血清铁分别为(14.93±9.72)μmol/L、(46.11±18.3)μmol/L缺铁组和正常组大鼠耳蜗组织铁含量分别为(179.80±24.70)pmol/L,(410.18±111.96)pmol/L;缺铁组大鼠听阈提高＞15dB的发生率远高于对照组。结论缺铁大鼠不仅血清铁降低,耳蜗组织铁也降低,同时影响到耳蜗听功能。
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| 关 键 词： | 耳蜗 微量元素 缺铁 耳聋 |
| 文章编号： | 1007-5496(2001)03-0063-02 |
| 修稿时间： | 2000-10-11 |
Iron decrease on auditary function of cochlear tissue in irondeficient rats |
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| Abstract: | Objective To determine the iron concentration in cochlear tissue and serum of iron - deficient rats and changes in auditorythershole. Method The determination of iron concentration in cochlear tissue and serum were assessed by atomic absorptin spectrophotometryafter reconstruction of iron-deficient rats. Results The concentration of iron in serun of iron - deficient group and normal group are( 14. 93 ±9. 72) μ mol/L、 (46. 11 ± 18. 3) μ mol/L. The iron concentration in cochlear tissue of iron - deficient group and normal group are ( 179. 80 ±24. 70) pmol/l, (410. 18 ± 111.96) pmol/L. Auditory threshold incresed by 15 db or more was more common in iron -dificient group comparedwith control group. Conclusion The concentration of iron in cochlear tissue and serum of iron - deficient rats are blow affecting auditory functionof cochlear tissues. |
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