奥氮平联合丙戊酸钠治疗双相躁狂的对照研究

目的比较奥氮平和氯丙嗪分别联合丙戊酸钠治疗双相障碍躁狂发作的疗效与安全性。方法将符合CCMD-3双相障碍躁狂发作诊断标准的70例患者随机分为两组,奥氮平组使用奥氮平联合丙戊酸钠,氯丙嗪组使用氯丙嗪联合丙戊酸钠,治疗6周,采用Bech-Rafaelsen躁狂量表(BRMS)和副反应量表(TESS)评定疗效及不良反应。结果两组BRMS总分及减分治疗后均有明显下降,两组间疗效无显著差异。起效均较快。除体重增加、困倦外,奥氮平组的不良反应少而轻微。结论奥氮平联合丙戊酸钠治疗双相障碍躁狂发作疗效肯定,安全性高,是临床上一种良好的选择。

Olanzapine or Chlorpromazine Combined with Sodium Valproate in Treatment of Manic Bipolar Affective Disorder:A Comparison Study

Objective To compare the efficacy and safety of olanzapine or chlorpromazine combined with Sodium valproate in the treatment of patients with manic bipolar affective disorder. Methods Seventy cases meeting criteria of CCMD-3 manic bipolar affective disorder were randomly divided into two groups： olanzapine group and chlorpromazine group. The olanzapine group was treated with olanzapine combined with Sodium valproate and the chlorpromazine group with chlorpromazine combined with Sodium valproate. The period of observation was 6 weeks. Bech-Rafaelsen Mania Rating （BRMS） and Treatment Emergent Symptom Scale （TESS） were used to evaluate the efficacy and side effect. Results In both groups, the total score and decreasing rate of BRMS were significantly reduced from baseline, with no significant differences between two groups. Both of them took effect more quickly. Side effects of the olanzapine group were fewer and mild except weight gain and somnolence. Conclusion The efficacy and safety of olanzapine combined with Sodium valproate are higher in manic bipolar affective disorder. It may be a good choice in the treatment of manic bipolar affective disorder.