Influence of morphine and naloxone on the release of noradrenaline from rat cerebellar cortex slices |
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Authors: | H. Montel K. Starke H. D. Taube |
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Affiliation: | (1) Klinikum Essen, Pharmakologisches Institut, Hufelandstraße 55, D-4300 Essen, Federal Republic of Germany;(2) Present address: Abteilung für Anästhesiologie, Klinikum der Universität Essen, Essen, Germany |
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Abstract: | Summary In slices of rat cerebellar cortex preincubated with (-)-3H-noradrenaline, the influence of morphine and naloxone on the efflux of tritium was investigated. The spontaneous outflow was not changed by 10–5 M of either morphine or naloxone. On the other hand, morphine caused a concentration-dependent decrease of the overflow, of tritium evoked by electrical field stimulation. Naloxone did not change the stimulation-induced overflow, but prevented its inhibition by morphine. It is concluded that morphine, through an action on opiate receptors located on cerebellar noradrenergic neurones, inhibits the secretion of the transmitter in response to nerve impulses. |
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Keywords: | Cerebellar Cortex Slices Noradrenaline Release Morphine Naloxone Opiate Receptors |
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