p73基因多态性与乳腺癌遗传易感性的关系

  目的  探讨p73基因G4C14-A4T14多态性与中国重庆地区汉族女性乳腺癌遗传易感性的关系。  方法  采用病例对照研究, 利用Sequenom Mass Array?iPLEX GOLD系统对170例乳腺癌患者和178例健康者对照的p73基因G4C14-A4T14单核苷酸多态性进行了检测, 并对检测结果进行t检验、χ2检验和非条件Logistic回归分析。  结果  p73基因G4C14-A4T14多态基因型和等位基因型在乳腺癌组和对照组的分布频率差异无统计学意义(χ2=2.750, P=0.253;χ2=2.195, P=0.138);与携带GC/AT和AT/AT基因型的个体比较, 携带GC/GC基因型的个体患三阴性乳腺癌发病风险显著增加(OR=2.992, 95%CI: 1.300~6.890, P=0.010)。  结论  p73基因G4C14-A4T14多态性与中国重庆地区汉族女性三阴性乳腺癌的发病风险相关, GC/GC基因型是中国重庆地区汉族女性三阴性乳腺癌的易感基因型; 携带GC/GC基因型的乳腺癌可能预后不良。 

Association of p73 Polymorphisms with Genetic Susceptibilities to Breast Cancer:A Case-control Study

  Objective  This study aims to evaluate the association between p73 G4C14-A4T14 polymorphisms and susceptibility to breast cancer in Chongqing women of Han Nationality in China.  Methods  In a case-control study of 170 breast cancer patients and 178 healthy controls, single nucleotide polymorphisms(SNPs)of p73 G4C14-A4T14 at exon 2 were genotyped by the Sequenom Mass Array? iPLEX GOLD System.Data were analyzed via t-test, Chi-square test, and logistic regression analysis.  Results  The distribution of p73 genotypes and allelotypes had no significant difference between the breast cancer patients and healthy controls(χ2=2.750, P=0.253;χ2=2.195, P=0.138).Individuals carrying the GC/GC genotype have a higher risk of developing triple negative breast cancer(TNBC)than individuals carrying the GC/AT and AT/AT genotypes(OR=2.992, 95%CI=1.300~6.890, P=0.010).  Conclusion  p73 G4C14-A4T14 polymorphisms are closely associated with the increased risk for TNBC in Chongqing women of Han Nationality in China.The GC/GC genotype is susceptible to TNBC in Chongqing women of Han Nationality in China.Breast cancer patients carrying the GC/GC genotype may have bad prognosis.