骨强度对骨量的影响及在临床上的应用

NIH提出诊断骨质疏松（OP）的必备条件是骨强度下降，健康人中的峰值骨骨强度差异大，明确影响骨强度而非骨质疏松病因的主要因素，并排除这些因素的影响后，有利于提高诊断OP的敏感度和准确度，目前已明确骨大小（骨投影面积和体积）和体重两个主要的影响因素，这两个影响因素标准化BMC后的骨量指标应用效果不同；为了在科研和临床中选择适当的骨量指标，本文对这些指标的几何特征、力学特征、与骨强度的关系和应用效果进行分析。

Effects of bone strength on bone mass and its clinical application

NIH indicates that the decrease of bone strength is the essential condition for diagnosis of osteoporosis. Because of bone strength between the period of peak bone mass in healthy crowd is disparity, it is profitable to improve sensitivity and accuracy for diagnosis of osteoporosis by identify the main factor to influence bone strength but not osteoperosis and eliminate it. At present, scholars have identified the bone size （bone projected area and volume） and weight are main influencing factors. Bone mass indexes which formed by BMC standardized by different influencing factors prosess different applicational effects. In order to select suitable bone mass index in scientific research and clinic, we compared these indexes in geometrical characteristic, mechanic characteristic, the relationship with bone strength and applicational effects.