| 外阴白色病变、鳞状上皮内瘤样变及外阴鳞状细胞癌中CD44v6的表达 |
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| 引用本文： | 刘明,曲群,宗璐,马玉琴.外阴白色病变、鳞状上皮内瘤样变及外阴鳞状细胞癌中CD44v6的表达[J].中国皮肤性病学杂志,2004,18(1):19-20,22. |
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| 作者姓名： | 刘明 曲群 宗璐 马玉琴 |
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| 作者单位： | 西安交通大学第二医院妇产科,陕西,西安,710004 |
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| 摘 要： | 目的 探讨CD44v6与外阴鳞状细胞癌发生、发展和侵袭转移的关系。方法 采用免疫组化SP法对外阴正常皮肤、外阴白色病变、鳞状上皮内瘤样变及外阴鳞状细胞癌中CD44v6进行检测。结果 正常皮肤无CD44v6表达 ;在外阴白色病变中其阳性率为 2 6.7%;鳞状上皮内瘤样变中为 5 3 .3 %;外阴鳞状细胞癌中为 73 .3 %。在外阴鳞状细胞癌中CD44v6阳性率与临床分期呈正相关 ;有淋巴结转移者阳性率为 92 .3 %,明显高于无淋巴结转移者 (P <0 .0 5 )。结论 CD44v6与外阴鳞状细胞癌淋巴结转移密切相关。
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| 关 键 词： | 外阴白色病变 鳞状上皮内瘤样变 外阴鳞状细胞癌 CD44v6 |
| 文章编号： | 1001-7089(2004)01-0019-02 |
Detection of CD44v6 in Chronic Vulvar Dystrophy,Vaginal Intraepithelial Neoplasia(VIN) and Vulvar Carcinoma |
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| LIU Ming,QU Qun,ZONG Lu,et al.Detection of CD44v6 in Chronic Vulvar Dystrophy,Vaginal Intraepithelial Neoplasia(VIN) and Vulvar Carcinoma[J].The Chinese Journal of Dermatovenereology,2004,18(1):19-20,22. |
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| Authors: | LIU Ming QU Qun ZONG Lu |
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| Abstract: | Objective To discuss the relationship between CD44v6 and genesis,development and metastasis of vulvar squamous carcanoma.Methods To detect CD44v6 in chronic vulvar dystrophy,VIN and vulvar carcinoma by immunohistochemical method S-P.Results No CD44v6 in normal epithelium.The positive rates of CD44v6 in chronic vulvar dystrophy,VIN and vulvar squamous carcinoma were 26.7%,53.3% and 73.3%.It had positive correlation with clinical stage of vulvar squamous carcinoma,The positive rate of CD44v6 in people with lymph nodes metastasis as 92.3% was higher than that of those without lymph nodes metastasis( P <0.05).Conclusion CD44v6 has close relationship with lymphnodes metastasis. |
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| Keywords: | Chronic vulvar dystrophy Vaginal intraepithelial neoplasia(VIN) Vulvar squamous carcinoma CD44v6 |
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