| 新型抗精神病药——齐哌西酮 |
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| 引用本文： | 潘桂花,李华芳. 新型抗精神病药——齐哌西酮[J]. 中国新药与临床杂志, 2003, 22(12): 746-750 |
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| 作者姓名： | 潘桂花 李华芳 |
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| 作者单位： | 上海市精神卫生中心,上海,200030 |
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| 摘 要： | 新型非典型抗精神病药———齐哌西酮(ziprasidone)是D2 ,5 HT2A,5 HT2C和 5 HT1受体强有力的拮抗剂。又是 5 HT1A受体的激动剂 ,同时还是 5 HT和NE的再摄取抑制剂。可以治疗精神分裂症和分裂情感性精神障碍的阳性症状、阴性症状、认知症状和情感症状。较少引起锥体外系不良反应 (EPS)和与高催乳素血症相关的症状 ,不会引起体重增加 ,但可引起QTC 间期延长
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| 关 键 词： | 抗精神病药 药理学 药动学 药物相互作用 齐哌西酮 药物不良反应 |
| 文章编号： | 1007-7669(2003)12-0746-05 |
| 修稿时间： | 2002-09-18 |
New antipsychotic drug--ziprasindone |
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| PAN Gui hua,LI Hua fang. New antipsychotic drug--ziprasindone[J]. Chinese Journal of New Drugs and Clinical Remedies, 2003, 22(12): 746-750 |
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| Authors: | PAN Gui hua LI Hua fang |
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| Abstract: | Ziprasidone is an atypical antipsychotic. It is a potent antagonist of D 2, 5 HT 2A , 5H 2C , and 5 HT 1 receptors, an agonist of 5 HT 1A receptors and an inhibitor of 5 HT and noradrenaline reuptake. It is used in the treatment of positive, negative and depressive symptoms of schizophrenia and schizoaffective disorder. It appears to be well tolerated and to cause few extrapyramidal adverse reactions or symptoms related to hyperprolactinaemia. Weight gain is uncommon. Ziprasidone can prolongate QTc interval of the electrocardiogram. |
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| Keywords: | antipsychotic agents pharmacology pharmacokinetics drug interactions ziprasidone adverse drug reaction |
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