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Empfehlungen für die Anwendung der Immunapherese bei der Therapie bullöser Autoimmundermatosen
Authors:Jan‐Ole Busch  Michael Sticherling
Abstract:The etiology of epidermolysis bullosa acquisita (EBA) is unknown. EBA may be associated with other autoim‐mune systemic diseases; it also has been described in connection with different malignant tumors, showing complete remission after successful treatment of the tumor.In such cases, EBA may be regarded as a paraneo‐plastic dermatosis. We detected a highly differentiated neuroendocrine pancreatic cancer in a 78‐year‐old woman with EBA. Even thought her tumor was completely removed and the patient has been disease‐free for over seven years, a complete regression of her autoimmune bullous dermatosis could not be induced. By using intravenous immunoglobulins in combination with mycophenolate mofetil, further blister formation could be ameliorated.
Keywords:Epidermolysis bullosa acquisita  neuroendocrine pancreatic cancer  intravenous immunoglobulins  mycophenolate mofetil
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