Reference viruses for seasonal and pandemic influenza vaccine preparation |
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Authors: | John M. Wood James S. Robertson |
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Affiliation: | 1.Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, UK. |
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Abstract: | The production of seasonal and pandemic influenza vaccines depends on the timely availability of suitable reference viruses. Seasonal vaccines are traditionally produced from high‐growth reassortant viruses, which have been derived empirically using well‐established techniques. However, it is not possible to use such approaches in deriving vaccine reference viruses from highly pathogenic H5N1 viruses and alternative techniques such as reverse genetics must be employed. |
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Keywords: | H5N1 high‐growth reassortants influenza vaccine viruses pandemic vaccine strains reverse genetics seasonal vaccine strains |
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