Effects of a new TRH analogue,YM-14673 on a passive avoidance test as a possible criterion of improvement in cognitive disturbance in rodents |
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Authors: | Minoru Yamamoto Masao Shimizu |
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Institution: | (1) Department of Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd., Azusawa 1-1-8, 174 Itabashi-Ku, Tokyo, Japan |
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Abstract: | Summary Effects of a new TRH analogue, YM-14673 (N -(S)-4-oxo-2-azetidinyl carbonyl]-l-histidyl-L-prolinamide dihydrate) on cognitive disturbance of passive avoidance response were studied in rodents in comparison with those of TRH and CDP-choline. The latency for entering from the illuminated into the dark compartments was shortened in anoxia and scopolamine-treated rats, cycloheximidetreated mice and cerebral ischemic gerbils. The shortened latency in these models was prolonged by administration of both YM-14673 and TRH in doses without effect on spontaneous movement. YM-14673 was about 10 times more potent than TRH in ameliorating the cognitive disturbance, whereas CDP-choline showed no influence on the learning ability. These results suggest that YM-14673 and TRH possess facilitatory effects on cerebral function and that YM-14673 was distinct from CDP-choline in pharmacological profile.
Send offprint requests to M. Yamamoto at the above address |
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Keywords: | TRH YM-14673 Passive avoidance Amnesia Scopolamine Anoxia Cerebral ischemia Cycloheximide |
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