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Insulin as an amyloid-fibril protein at sites of repeated insulin injections in a diabetic patient |
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| Authors: | Dr. F. E. Dische C. Wernstedt G. T. Westermark P. Westermark M. B. Pepys J. A. Rennie S. G. Gilbey P. J. Watkins |
| Affiliation: | (1) Department of Morbid Anatomy, King's College School of Medicine and Dentistry, and King's College Hospital, UK;(2) Department of Surgery, King's College School of Medicine and Dentistry, and King's College Hospital, UK;(3) Department of Diabetic Clinic, King's College School of Medicine and Dentistry, and King's College Hospital, UK;(4) Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, London, UK;(5) Ludwig Institute for Cancer Research, Uppsala Branch, Sweden;(6) Department of Pathology, University Hospital, Uppsala, Sweden;(7) Department of Pathology, Dulwich Hospital, SE22 8PT London, UK |
| Abstract: | Summary A patient with Type 1 (insulin-dependent) diabetes mellitus developed localised amyloidosis at the sites of his injections of porcine insulin. A major amyloid fibril protein was extracted and, by means of its amino acid composition and amino acid sequence, it was shown to contain intact insulin molecules. Porcine insulin is the tenth protein and the first foreign protein to be chemically identified in human amyloid fibrils. |
| Keywords: | Diabetes mellitus insulin localised amyloidosis amino acid sequence analysis |
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