| rIL-2治疗单纯疱疹性角膜炎的临床研究 |
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| 引用本文： | 智淑萍,杨伏兰,梁春华,孙晓香.rIL-2治疗单纯疱疹性角膜炎的临床研究[J].中国实用眼科杂志,2001,19(8):604-605. |
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| 作者姓名： | 智淑萍 杨伏兰 梁春华 孙晓香 |
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| 作者单位： | 1. 山东济宁医学院附属医院眼科,
2. 山东金乡县人民医院眼科 |
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| 摘 要： | 目的：研究重组白细胞介素Ⅱ（rIL-2）治疗单纯疱疹性角膜炎（HSK）的疗效及预防复发的作用。方法：将确诊的HSK患者随机分为2组，治疗组38例在应用无环鸟苷滴眼液同时联合rIL-2局部及全身应用；对照组30例单纯应用无环鸟苷治疗。治愈后均随访2年。结果：联合用药治疗组的病程较对照组明显缩短（P＜0．01）。随访结果显示，治疗组的复发率较对照组明显降低（P＜0．05）。结论：临床应用rIL-2联合抗病毒药物治疗HSK疗效明显，可缩短病程、降低复发率。临床观察无明显不良反应。
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| 关 键 词： | 单纯疱疹性角膜炎 白细胞介素Ⅱ 临床研究 rIL－2 |
Clinical study of curing herpes simplex keratitis with rlL-2 |
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| Zhi Shuping,Sun Xiaoxiang,et al.Clinical study of curing herpes simplex keratitis with rlL-2[J].Chinese Journal of Practical Ophthalmology,2001,19(8):604-605. |
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| Authors: | Zhi Shuping Sun Xiaoxiang |
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| Institution: | Zhi Shuping,Sun Xiaoxiang,et al Department of Ophthalmology,Affiliated Hospital of Jining Medical College,Shandong 272129 |
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| Abstract: | Objectives: To study the effect of rIL-2 in the treatment of Herpes Simplex Keratitis (HSK) and its prognostic effect in the recurrence of HSK. Methods: Patients of HSK were parted into 2 groups randomly. 38 cases in the experiment group were treated with combination application of acyclovir and rIL-2, and 30 cases in the control group were treated with acyclovir simply. The patients were followed up for one and half year. Results: The therapy course of the experiment group was significantly shorter than that of the control group (P<0.01). The recurrence rate of the experiment group was less than that of the control group (P<0.05). Conclusions: Using rIL-2 combined with antivirus drugs for HSK can decrease the time of therapy and reduce recurrence rate. |
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| Keywords: | Herpes simplex keratitis IL-2 |
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