小柴胡汤治疗肾病综合征机理的探讨

为从糖皮质激素受体（ＧＣＲ）角度探讨小柴胡汤治疗肾病综合征（ＮＳ）的机理，应用放射配体结合分析法测定人外周血白细胞ＧＣＲ水平。结果表明，单独使用小柴胡汤可减少ＮＳ患者２４ｈ尿蛋白量，但降低蛋白作用缓慢；在用激素后加用小柴胡汤，ＮＳ患者２４ｈ尿蛋白量可进一步减少。小柴胡汤和激素均能使患者ＧＣＲ水平明显下降（Ｐ＜０．０１），提示小柴胡汤具有糖皮质激素（ＧＣ）样作用；患者在应用激素治疗有效后开始减量，蛋白尿回升时，加用小柴胡汤，患者ＧＣＲ水平明显回升（Ｐ＜０．０１），提示小柴胡汤对ＧＣＲ具有双向调节作用

STUDY ON MECHANISM OF TREATING NEPHROTIC SYNDROME USING XIAO CHAIHU TANG

To Study the mechanism of Xiao Chai hu Tang in treating nephrotic syndrome (NS) from the point of glucocorticoid receptor (GCR), radioligand binding assay was used. The results showed that Xiao Chai hu Tang can markedly reduce 24h urine protein of the patients, but slowly than that of glucocorticoid (GC). When Xiao Chai hu Tang was used in the treatment with GC, 24h urine protein of the patients further decreased. The significant falls of the GCR lever were observed in the patients both with GC treatment and with Xiao Chai hu Tangtreatment. The GCR levels of the patients were obviously improved during the treatment with GC plus Xiao Chai hu Tang. Xiao Chai hu Tang may give play to its effects by way of GCR.