慢性胆管疾病病人胆汁细菌培养及其药敏分析

①目的 探讨慢性胆管疾病的主要病原菌及药敏谱，以指导临床正确诊断和治疗。②方法 对临床巳确诊的慢性胆囊炎，胆石症并发感染，梗阻性黄疸、慢性胆囊炎急性发作病人65例的胆汁进行细菌培养，同时进行菌群鉴定及快速药敏试验。③结果 65例标本中共检出感染细菌134株，其中革兰阴性菌占88.1%，革兰阳性菌占11.9%，药敏试验结果显示丁胺卡那霉素，环丙沙星对大肠杆菌、沙雷菌、铜绿假单胞菌有较高的抗菌活性。④结论 慢性胆管疾病是多种类型菌混合感染所致。丁胺卡那霉素，环丙沙星治疗效果较好。

BACTERIA CULTURE AND ANTIBIOTIC SUSCEPTIBILITY DETERMINATION OF BILE SAMPLES FROM PATIENTS WITH CHRONIC BILIARY TRACT DISEASES

Objective To investigate the main pathogenic bacteria of chronic cholecystitis and antibiotic susceptibility so as to guide the diagnosis and treatment of the disease in clinical practice. Methods The bile samples were collected from 65 patients with chronic cholecystitis, cholelithiasis, obstructive jaundice and acute attack of chronic cholecystitis. The types and strains of the bacteria in bile were determined by bacteria culture, a quick test for sensitivity to antibiotics was taken. Results 134 strains were detected from the collected samples. 88.1% of them were gram negative,and 11.9% gram positive. The test for sensitivity showed that amikacin and ciprofloxacin had high activities to E.coli, S.marcescens and P.aeruginosa, respectively. Conclusion Chronic biliary tract diseases might be caused by mixed infection of various bacteria. Amikacin and ciprofloxacin have a better therapeutic effect.