Effect of clofibrate in non-hemolytic indirect hyperbilirubinemia in full term neonates |
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Authors: | Fatemeh Eghbalian Abolfazl Pourhossein Hassan Zandevakili |
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Institution: | (1) Department of Pediatrics, Hamadan University of Medical Sciences Bessat Hospital, Hamadan, Iran |
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Abstract: | Objective Jaundice is a common clinical problem in neonatal period which may result in brain damage even in healthy full term newborns,
when it is severe. The aim of this study was to characterize the therapeutic effect of clofibrate in full term neonates who
present with nonhemolytic jaundice.
Methods A clinical controlled study was performed on 60 full term neonates who presented with non-hemolytic jaundice. 30 neonates
were treated with a single oral dose of clofibrate (100 mg/Kg) plus phototherapy (case group), while 30 neonates received
only phototherapy (control group). Both groups were compared in regard to post therapeutic mean total and indirect plasma
bilirubin levels, admission duration and the rate of exchange transfusion.
Results The reduction rate of total and indirect plasma bilirubin levels were significantly higher in the clofibrate-treated group
as compared with the control group (P<0.05). The mean duration of admission was found to be reduced from 2.9 +/− 0.9 days
in the control groupl to 2.2 +/− 0.6 days in clofibrate-treated group (P=0.002). The mean plasma total bilirubin level was
lower in the clofibrate-treated group. No cases required phototherapy after 48 hour in clofibrate-treated group, while 9 neonates
(30%) and 2 neonates (6.7%) required phototherapy after 72 hour and 96 hour respectively in the control group. There was no
difference between both the groups for sex, the time of developing jaundice and the rate of exchange transfusion.
Conclusion A single dose of clofibrate (100 mg/Kg) alongwith phototherapy is more effective than phototherapy alone in treating non-hemolytic
hyperbilirubinemia in term healthy newborn infants. |
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Keywords: | Neonate Clofibrate Jaundice |
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