| 外源性哮喘患者白细胞介素2和可溶性白细胞介素2受体的测定 |
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| 引用本文： | 刘光辉,彭慧,陈欢,李洪,梁智辉,王立人,冯玮.外源性哮喘患者白细胞介素2和可溶性白细胞介素2受体的测定[J].华中科技大学学报(医学版),1998(5). |
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| 作者姓名： | 刘光辉 彭慧 陈欢 李洪 梁智辉 王立人 冯玮 |
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| 作者单位： | 同济医科大学附属同济医院变态反应科 武汉430030(刘光辉，彭慧，陈欢)，同济医科大学附属协和医院内科 武汉430022(李洪)，同济医科大学基础医学院免疫学教研室 武汉430030(梁智辉，王立人，冯玮) |
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| 摘 要： | 采用酶联双抗体夹心法,对36例哮喘患者和54例正常献血者(对照组)进行了外周血单个核细胞诱生白细介素2(IL-2)水平的检测。结果;哮喘组外周血单个核细胞诱生的IL-2活性吸光度(A)值]为0.2015±0.0225,血浆可溶白细胞介素2(sIL-2)水平为167.5±52.4kU/L,均高于对照组前者A值为0.1881±0.0300,后者为(114.2±48.6)kU/L(P<0.05,P<0.01)]。提示:外源性哮喘患者发病中存在着T淋巴细胞的活化,导致IL-2诱生水平和血浆sIL-2R水平的增高,二者在哮喘发病机制中起着一定的作用。
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| 关 键 词： | 哮喘 白细胞介素2 受体 白细胞介素2 |
Determination of Interleukin-2 and Soluble Interleukin-2 Receptor in Exogenous Asthma Patients |
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| Liu Guanghui',Li Hong,Liang Zhihui et al Allergy.Determination of Interleukin-2 and Soluble Interleukin-2 Receptor in Exogenous Asthma Patients[J].Journal of Huazhong University of Science and Technology(Health Sciences),1998(5). |
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| Authors: | Liu Guanghui' Li Hong Liang Zhihui Allergy |
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| Institution: | Liu Guanghui',Li Hong2,Liang Zhihui3 et al1 Allergy Department,Tongji Hospital,Tongji Medical University,Wuhan 430030 1 Department of Internal Medicine,Xiehe Hospital,Tongji Medical University,Wuhan 430022 3 Department of Immunology,School of Basic Medical Sciences,Tangji Medical University,Wuhan 430030 |
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| Abstract: | The enzyme-linked double antibody with jam center method was employed to determine the induced interleukin-2(IL-2) activity in supernatant of peripheral blood mononuclear cells (PBMC) in 36 cases of asthma and 54 blood donors as normal controls. It was showed that the induced IL-2 activity in PBMC was 0. 201 5?. 022 5 (A value) and soluble IL-2 receptor (sIL-2R) level (167. 5?2. 4) kU/L in asthma pa-tients,which was higher than in the normal controls the former A value 0. 188 1?. 030 0.the latter (114. 2 ?8. 6) kU/L,P<0. 05,P<0. 01)]. PBMC and sIL-2R levels in plasma were determined in 36 patients with asthma. It was concluded that T lymphocytes are acitvated in exogenous asthma patients so as to result in the elevation of the induced IL-2 activity and plasma sIL-2R levels,which plays certain roles in the pathogenesis of exogenous asthma. |
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| Keywords: | allergic asthma interleukin-2 receptor soluble interleukin-2 |
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