胺碘酮与起搏器联合治疗病窦综合征并阵发性心房颤动的观察

观察胺碘酮与起搏器联合治疗病窦综合征并阵发性心房颤动 (简称房颤 )有效性及安全性。 52例慢 快综合征患者 ,起搏器治疗后仍有阵发性房颤 (经心电图和动态心电图证实 ) ,在停用其他抗心律失常药物至少 5个半衰期后 ,按标准方案给予胺碘酮治疗 :负荷量 0 .2g,3次 /天 ,7天 ;继以 0 .2g,2次 /天 ,7天 ;维持量为 0 .2g ,1次 /天 ,连续服用 3个月。根据临床症状和动态心电图评价疗效及安全性。结果 :观察 9.6± 1 3 .5(2 .7～ 2 8)个月 ,总有效率为 69.2 % ,动态心电图自身心律所占时间 ,治疗前为 7.6± 3 .2 (5 .5～ 1 2 .5)h/d ,治疗后为 3 .4± 2 .6(0～ 7.2 )h/d(P <0 .0 1 ) ;在随访期间有 2例促甲状腺素轻度升高 ,经调整剂量后恢复正常 ;1例皮肤搔痒 ,经减量后症状消失。结论 :胺碘酮与起搏器联合治疗病窦综合征并阵发性房颤是安全有效的

Effects of Amiodarone on Paroxysmal Atrial Fibrillation in The Patients With Pacemaker

To evaluate the effects and safty of amiodarone combination with pacemaker on paroxysmal atrial fibrillation(AF) accompanying with bradycardia-tachycardi a syndrome,52 patients with AF,which were treated by pacemaker because of bradyc ardia,were orally given amiodarone according to standard regime.The effectivenes s was evaluated by clinical symptom and Holter monitoring.Results:Within 9.6±13 .5(2.7～28) months follow-up,the total effective rate of amiodarone was 69.2%; significant side effects weren′t found.Conclusion:It is effective and safe for amiodarone combination with pacemaker to treat paroxysmal AF in patients with b radycardia-tachycardia syndrome.