Dynamic Contrast-enhanced Magnetic Resonance Imaging: Applications in Oncology |
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| Affiliation: | 1. Duke NUS Graduate Medical School Singapore, Singapore;2. Department of Oncologic Imaging, National Cancer Centre Singapore, Singapore;3. Department of Medical Oncology, National Cancer Centre Singapore, Singapore;1. Department of Oncology, University of Navarre, Pamplona, Spain;2. Department of Orthopaedic Surgery, University of Navarre, Pamplona, Spain;3. Department of Oncology, Hospital San Jaime, Torrevieja, Spain;4. Department of Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain;1. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran;2. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran;1. Department of urology, institut Jules-Bordet, université libre de Bruxelles (ULB), Brussels, Belgium;2. Department of urology, cliniques universitaires de Bruxelles, hôpital Erasme, ULB, Brussels, Belgium;3. Department of urology, Hôtel-Dieu de France, Beirut, Lebanon;4. Department of oncology, Hôtel-Dieu de France, Beirut, Lebanon;5. Department of radiology, institut Jules-Bordet, ULB, Brussels, Belgium;6. Department of statistics, institut Jules-Bordet, ULB, Brussels, Belgium;1. Department of Neurosurgery, National Cerebral and Cardiovascular Center, Osaka, Japan;2. Department of Radiology, National Cerebral and Cardiovascular Center, Osaka, Japan;3. Department of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan |
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| Abstract: | Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) allows functional characterisation of tissue perfusion characteristics and acts as a biomarker for tumour angiogenesis. It involves serial acquisition of MRI images before and after injection of contrast, as such, tissue perfusion and permeability can be assessed based on the signal enhancement kinetics. The ability to evaluate whole tumour volumes in a non-invasive manner makes DCE MRI especially attractive for potential oncological applications. Here we provide an overview of the current research involving DCE MRI as a biomarker for the diagnosis and characterisation of malignancies, prediction of the therapeutic response and survival outcomes, as well as radiation therapy planning. |
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| Keywords: | Angiogenesis dynamic contrast-enhanced imaging functional imaging magnetic resonance imaging perfusion imaging |
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