Comparison of prognostic impact of absolute lymphocyte count,absolute monocyte count,absolute lymphocyte count/absolute monocyte count prognostic score and ratio in patients with diffuse large B cell lymphoma |
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| Affiliation: | 1. Clinical Hospital Center “Bezanijska Kosa”, Belgrade, Serbia;2. Institute of Oncology, Sremska Kamenica, Serbia;3. Institute of Statistics, Clinical Center of Serbia, Belgrade, Serbia;4. Institute of Hematology, Clinical Center of Serbia, Belgrade, Serbia;5. Faculty of Medicine, University of Belgrade, Serbia;6. Faculty of Medicine University of Novi Sad, Serbia;1. Ankara University School of Medicine, Department of Gastroenterology, Ankara, Turkey;2. Ankara University School of Medicine, Department of Biostatistics, Ankara, Turkey;3. Ankara University School of Medicine, Department of Immunology, Ankara, Turkey;1. Department of Obesity Medicine and Endocrinology, Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, UK;2. Manchester Medical School, The University of Manchester, Manchester, UK;3. Department of Respiratory Medicine, Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, UK;1. Italian National Blood Centre, National Institute of Health, Rome, Italy;2. Faculty of Medicine and Psychology, “Sapienza” University of Rome, Italy;3. IRCCS Cà Granda Foundation Maggiore Policlinico Hospital, Milan, Italy;4. Immunohaematology, Transfusion Medicine and Clinical Pathology Units, "San Giovanni Calibita" Fatebenefratelli Hospital, AFAR, Rome, Italy;1. Department of Biochemistry, BPS Govt. Medical College, Haryana, India;2. Department of Biochemistry, Sri Muthukumaran Medical College, Tamil Nadu, India;3. Department of Biochemistry, SVIMS University, Andhra Pradesh, India;4. Department of Biochemistry, NABL, Haryana, India |
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| Abstract: | BackgroundThe combination of absolute lymphocyte count (ALC) and absolute monocyte count (AMC) at diagnosis has prognostic relevance in patients with diffuse large B cell lymphoma (DLBCL).AimsThe present study was designed to investigate the prognostic significance of ALC and AMC and to determine whether ALC/AMC ratio or ALC/AMC prognostic score is better predictor of outcome in DLBCL.MethodsWe retrospectively analyzed the prognostic significance of ALC and AMC, ALC/AMC ratio and ALC/AMC prognostic score at diagnosis in 222 DLBCL patients treated with R-CHOP.ResultsROC analysis showed that optimal cut-off values of AMC and ALC/AMC ratio with the best sensitivity and specificity were 0.59 × 109/L and 2.8, respectively. Cut-off of ALC was determined according to the literature data (1 × 109/L). Low ALC, high AMC, low ALC/AMC ratio and high ALC/AMC prognostic score were in significant association with lower rate of therapy response and survival. In contrast, these parameters were not in significant correlation with relapse rate. The patients with low ALC, “high” AMC, low ALC/AMC ratio and high ALC/AMC prognostic score at diagnosis had significantly shorter EFS and OS. In multivariate analysis all tested parameters (ALC, AMC, ALC/AMC prognostic score and ALC/AMC ratio) are independent risk factors along with “bulky” disease and IPI.ConclusionAll tested parameters (ALC, AMC, ALC/AMC score and ALC/AMC ratio) may be useful prognostic factors in DLBCL patients. ALC/AMC score has a slight advantage as it allows the classification of patients into three prognostic groups. Further studies are needed to determine which of these parameters has the highest predictive value. |
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