Low seroprevalance of diphtheria,tetanus and pertussis in ambulatory adult patients: the need for lifelong vaccination |
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| Affiliation: | 1. Hacettepe University Faculty of Medicine, Department of Internal Medicine, Section of General Internal Medicine, 06100, Sıhhiye, Ankara, Turkey;2. Hacettepe University Faculty of Medicine, Department of Infectious Diseases Clinical Microbiology, 06100, Sıhhiye, Ankara, Turkey;3. Hacettepe University Faculty of Medicine, Department of Internal Medicine, Section of Geriatrics, 06100, Sıhhiye, Ankara, Turkey;1. Department of Internal Medicine, Collagen and Minoritarian Diseases, Virgen del Rocio Hospital, Seville, Spain;2. Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic Foundation, Cleveland, OH, USA;1. Univ Bordeaux, Inserm U657, F33000 Bordeaux, France;2. Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco”, Università di Milano, I20157 Milan, Italy;3. CHU Bordeaux, F33000 Bordeaux, France;4. Regional Centre for Pharmacovigilance, Lombardy Region, via Rosellini 17, I20124 Milan, Italy;5. E. Medea Scientific Institute, I23842 Bosisio Parini, Italy;1. Department of General Surgery, Sakarya University, Faculty of Medicine, Sakarya, Turkey;2. Department of Gastroenterology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey;3. Department of Gastroenterological Surgery, Turkiye Yuksek Ihtisas Teaching and Research Hospital, Ankara, Turkey;1. Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, People''s Republic of China;2. Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518054, People''s Republic of China;3. Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, 315211, People''s Republic of China;4. Shenzhen Xili People''s Hospital, Shenzhen, 518054, People''s Republic of China |
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| Abstract: | BackgroundTetanus, diphtheria, pertussis and measles are vaccine preventable diseases that have been reported to cause morbidity and mortality in adult population in the recent years. We aimed to document the seropositivity rates and vaccination indication for these four vaccine preventable diseases among adult and elderly patients who were seen as outpatients in a university hospital.MethodsBlood samples for tetanus, diphtheria, pertussis and measles antibodies were obtained. Results were evaluated with regards to protection levels and booster vaccine indications according to the cut-off values.ResultsA total of 1367 patients consented for the study and 1303 blood samples were available for analysis at the end of the study. The antibody levels against measles conferred protection in 98% of patients. However, 65% of the patients had no protection for diphtheria, 69% had no protection for tetanus and 90% of the patients had no protection for pertussis. Only 1.3% of the study population had seropositivity against three of the diseases—Tdap booster was indicated in 98.7%. Multivariable logistic regression showed that tetanus protection decreased with increasing age. Having a chronic disease was associated with a lower rate of protective antibodies for pertussis.ConclusionsWe demonstrated very low rates of protection against three of the vaccine preventable diseases of childhood—diphtheria, pertussis and tetanus. Booster vaccinations are required in adult life in accordance with national and international adult vaccination guidelines. The concept of “lifelong vaccination” should be implemented and every encounter with the patient should be regarded as a chance for catch-up. |
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